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Aging and rejuvenation of neural stem cells and their niches
Aging has a profound and devastating effect on the brain. Old age is accompanied by
declining cognitive function and enhanced risk of brain diseases, including cancer and …
declining cognitive function and enhanced risk of brain diseases, including cancer and …
Radial glia in the zebrafish brain: Functional, structural, and physiological comparison with the mammalian glia
The neuroscience community has witnessed a tremendous expansion of glia research. Glial
cells are now on center stage with leading roles in the development, maturation, and …
cells are now on center stage with leading roles in the development, maturation, and …
Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis
Fat mass and obesity-associated gene (FTO) is a member of the Fe (II)-and oxoglutarate-
dependent AlkB dioxygenase family and is linked to both obesity and intellectual disability …
dependent AlkB dioxygenase family and is linked to both obesity and intellectual disability …
Single-cell transcriptomics analyses of neural stem cell heterogeneity and contextual plasticity in a zebrafish brain model of amyloid toxicity
The neural stem cell (NSC) reservoir can be harnessed for stem cell-based regenerative
therapies. Zebrafish remarkably regenerate their brain by inducing NSC plasticity in a …
therapies. Zebrafish remarkably regenerate their brain by inducing NSC plasticity in a …
Therapeutic plasticity of neural stem cells
Neural stem cells (NSCs) have garnered significant scientific and commercial interest in the
last 15 years. Given their plasticity, defined as the ability to develop into different phenotypes …
last 15 years. Given their plasticity, defined as the ability to develop into different phenotypes …
Cross‐talk between monocyte invasion and astrocyte proliferation regulates scarring in brain injury
Scar formation after brain injury is still poorly understood. To further elucidate such
processes, here, we examine the interplay between astrocyte proliferation taking place …
processes, here, we examine the interplay between astrocyte proliferation taking place …
Common and distinct features of adult neurogenesis and regeneration in the telencephalon of zebrafish and mammals
In contrast to mammals, the adult zebrafish brain shows neurogenic activity in a multitude of
niches present in almost all brain subdivisions. Irrespectively, constitutive neurogenesis in …
niches present in almost all brain subdivisions. Irrespectively, constitutive neurogenesis in …
Notch and neurogenesis
Neurogenesis is the process of forming neurons and is essential during vertebrate
development to produce most of the neurons of the adult brain. However, neurogenesis …
development to produce most of the neurons of the adult brain. However, neurogenesis …
Single cell sequencing of radial glia progeny reveals the diversity of newborn neurons in the adult zebrafish brain
Zebrafish display widespread and pronounced adult neurogenesis, which is fundamental for
their regeneration capability after central nervous system injury. However, the cellular …
their regeneration capability after central nervous system injury. However, the cellular …
New neurons in adult brain: distribution, molecular mechanisms and therapies
Abstract “Are new neurons added in the adult mammalian brain?”“Do neural stem cells
activate following CNS diseases?”“How can we modulate their activation to promote …
activate following CNS diseases?”“How can we modulate their activation to promote …