Directed evolution: methodologies and applications

Y Wang, P Xue, M Cao, T Yu, ST Lane… - Chemical reviews, 2021 - ACS Publications
Directed evolution aims to expedite the natural evolution process of biological molecules
and systems in a test tube through iterative rounds of gene diversifications and library …

Biosensing with dnazymes

EM McConnell, I Cozma, Q Mou, JD Brennan… - Chemical Society …, 2021 - pubs.rsc.org
This article provides a comprehensive review of biosensing with DNAzymes, providing an
overview of different sensing applications while highlighting major progress and seminal …

Fluorescent and colorimetric sensors for detection of lead, cadmium, and mercury ions

HN Kim, WX Ren, JS Kim, J Yoon - Chemical Society Reviews, 2012 - pubs.rsc.org
Exposure to even very low levels of lead, cadmium, and mercury ions is known to cause
neurological, reproductive, cardiovascular, and developmental disorders, which are more …

Metal sensing by DNA

W Zhou, R Saran, J Liu - Chemical reviews, 2017 - ACS Publications
Metal ions are essential to many chemical, biological, and environmental processes. In the
past two decades, many DNA-based metal sensors have emerged. While the main …

Functional nucleic acid sensors

J Liu, Z Cao, Y Lu - Chemical reviews, 2009 - ACS Publications
Sensors are devices that respond to physical or chemical stimuli and produce detectable
signals. 1r4 They are a critical extension of human perception of the world in many aspects …

Nucleic acid tests for clinical translation

M Li, F Yin, L Song, X Mao, F Li, C Fan, X Zuo… - Chemical …, 2021 - ACS Publications
Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are
natural biopolymers composed of nucleotides that store, transmit, and express genetic …

A colorimetric lead biosensor using DNAzyme-directed assembly of gold nanoparticles

J Liu, Y Lu - Journal of the American Chemical Society, 2003 - ACS Publications
A highly sensitive and selective colorimetric lead biosensor based on DNAzyme-directed
assembly of gold nanoparticles is reported. It consists of a DNAzyme and its substrate that …

Functional nucleic acid-based hydrogels for bioanalytical and biomedical applications

J Li, L Mo, CH Lu, T Fu, HH Yang, W Tan - Chemical Society Reviews, 2016 - pubs.rsc.org
Hydrogels are crosslinked hydrophilic polymers that can absorb a large amount of water. By
their hydrophilic, biocompatible and highly tunable nature, hydrogels can be tailored for …

Therapeutic DNAzymes: from structure design to clinical applications

J Yan, M Ran, X Shen, H Zhang - Advanced Materials, 2023 - Wiley Online Library
Therapeutic DNAzymes have unceasingly intrigued the scientific community owing to their
prosperous gene regulation capability. The efficacy of DNAzymes against many types of …

[HTML][HTML] From cascaded catalytic nucleic acids to enzyme–DNA nanostructures: controlling reactivity, sensing, logic operations, and assembly of complex structures

F Wang, CH Lu, I Willner - Chemical reviews, 2014 - ACS Publications
DNA is one of the most fascinating biopolymers. Besides its central role as carrier of genetic
information and translation of the genetic code into proteins, DNA holds great promise as a …