[HTML][HTML] Osteoblast differentiation and signaling: established concepts and emerging topics

M Ponzetti, N Rucci - International Journal of Molecular Sciences, 2021 - mdpi.com
Osteoblasts, the cells that build up our skeleton, are remarkably versatile and important cells
that need tight regulation in all the phases of their differentiation to guarantee proper skeletal …

Insights and implications of sexual dimorphism in osteoporosis

YY Zhang, N **e, XD Sun, EC Nice, YC Liou, C Huang… - Bone research, 2024 - nature.com
Osteoporosis, a metabolic bone disease characterized by low bone mineral density and
deterioration of bone microarchitecture, has led to a high risk of fatal osteoporotic fractures …

[HTML][HTML] Sirt3-mediated mitophagy regulates AGEs-induced BMSCs senescence and senile osteoporosis

Y Guo, X Jia, Y Cui, Y Song, S Wang, Y Geng, R Li… - Redox biology, 2021 - Elsevier
Senile osteoporosis (SOP) is widely regarded as one of the typical aging-related diseases
due to a decrease in bone mass and the destruction in microarchitecture. The inhibition of …

Age related osteoporosis: targeting cellular senescence

U Föger-Samwald, K Kerschan-Schindl… - International journal of …, 2022 - mdpi.com
Age-related chronic diseases are an enormous burden to modern societies worldwide.
Among these, osteoporosis, a condition that predisposes individuals to an increased risk of …

[HTML][HTML] Exosomes from young plasma alleviate osteoporosis through miR-217-5p-regulated osteogenesis of bone marrow mesenchymal stem cell

F Meng, G Wang, F Zhou, G Li, M Wang, Z Zhou… - Composites Part B …, 2024 - Elsevier
Osteoporosis, increasingly prevalent among the aging population, poses a global health
challenge. Current treatments, often limited by prolonged treatment durations, serious side …

[HTML][HTML] Biodegradable Zn-2Cu-0.5 Zr alloy promotes the bone repair of senile osteoporotic fractures via the immune-modulation of macrophages

H Ji, G Shen, H Liu, Y Liu, J Qian, GJ Wan, E Luo - Bioactive Materials, 2024 - Elsevier
Delayed bone-healing of senile osteoporotic fractures remains a clinical challenge due to
the alterations caused by aging in bone and immune systems. The novel biomaterials that …

Melatonin inhibits the ferroptosis pathway in rat bone marrow mesenchymal stem cells by activating the PI3K/AKT/mTOR signaling axis to attenuate steroid‐induced …

M Li, N Yang, L Hao, W Zhou, L Li, L Liu… - Oxidative medicine …, 2022 - Wiley Online Library
Steroid‐induced osteoporosis (SIOP) is a form of secondary osteoporosis, but its specific
mechanism remains unclear. Glucocorticoid (GC‐)‐induced death of osteoblasts and bone …

[HTML][HTML] A mini review on osteoporosis: from biology to pharmacological management of bone loss

KY Chin, BN Ng, MKI Rostam… - Journal of Clinical …, 2022 - mdpi.com
Osteoporosis refers to excessive bone loss as reflected by the deterioration of bone mass
and microarchitecture, which compromises bone strength. It is a complex multifactorial …

Gender differences in osteoporosis: a single-center observational study

M De Martinis, MM Sirufo, M Polsinelli… - The world journal of …, 2020 - pmc.ncbi.nlm.nih.gov
Purpose Osteoporosis affects more than 200 million people worldwide: its prevalence
increases with age and is actually growing due to the constant population aging. Women are …

Enhancing osteoporosis treatment with engineered mesenchymal stem cell-derived extracellular vesicles: mechanisms and advances

Y Chen, Y Huang, J Li, T Jiao, L Yang - Cell death & disease, 2024 - nature.com
As societal aging intensifies, the incidence of osteoporosis (OP) continually rises. OP is a
skeletal disorder characterized by reduced bone mass, deteriorated bone tissue …