The healthy human microbiome

J Lloyd-Price, G Abu-Ali, C Huttenhower - Genome medicine, 2016 - Springer
Humans are virtually identical in their genetic makeup, yet the small differences in our DNA
give rise to tremendous phenotypic diversity across the human population. By contrast, the …

Mining the microbiota for microbial and metabolite-based immunotherapies

AN Skelly, Y Sato, S Kearney, K Honda - Nature Reviews Immunology, 2019 - nature.com
Trillions of microorganisms transit through and reside in the mammalian gastrointestinal tract
each day, collectively producing thousands of small molecules and metabolites with local …

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals

F Asnicar, SE Berry, AM Valdes, LH Nguyen… - Nature medicine, 2021 - nature.com
The gut microbiome is shaped by diet and influences host metabolism; however, these links
are complex and can be unique to each individual. We performed deep metagenomic …

Intestinal Blastocystis is linked to healthier diets and more favorable cardiometabolic outcomes in 56,989 individuals from 32 countries

E Piperni, LH Nguyen, P Manghi, H Kim, E Pasolli… - Cell, 2024 - cell.com
Diet impacts human health, influencing body adiposity and the risk of develo**
cardiometabolic diseases. The gut microbiome is a key player in the diet-health axis, but …

A metabolite-triggered tuft cell-ILC2 circuit drives small intestinal remodeling

C Schneider, CE O'Leary, J von Moltke, HE Liang… - Cell, 2018 - cell.com
The small intestinal tuft cell-ILC2 circuit mediates epithelial responses to intestinal helminths
and protists by tuft cell chemosensory-like sensing and IL-25-mediated activation of lamina …

New insights into the interactions between Blastocystis, the gut microbiota, and host immunity

L Deng, L Wojciech, NRJ Gascoigne, G Peng… - PLoS …, 2021 - journals.plos.org
The human gut microbiota is a diverse and complex ecosystem that is involved in beneficial
physiological functions as well as disease pathogenesis. Blastocystis is a common protistan …

[HTML][HTML] Host-protozoan interactions protect from mucosal infections through activation of the inflammasome

A Chudnovskiy, A Mortha, V Kana, A Kennard… - Cell, 2016 - cell.com
While conventional pathogenic protists have been extensively studied, there is an
underappreciated constitutive protist microbiota that is an integral part of the vertebrate …

Succinate metabolism and its regulation of host-microbe interactions

Y Wei, X Ma, JC Zhao, XQ Wang, CQ Gao - Gut Microbes, 2023 - Taylor & Francis
Succinate is a circulating metabolite, and the relationship between abnormal changes in the
physiological concentration of succinate and inflammatory diseases caused by the …

Epidemiology and subtype distribution of Blastocystis in humans: a review

S Popruk, DEV Adao, WL Rivera - Infection, Genetics and Evolution, 2021 - Elsevier
Blastocystis is a commonly encountered gastrointestinal protozoan in humans and animals
with uncertain pathogenicity. Despite its potential public health impact, epidemiological data …

Pathogenic mechanisms of Cryptosporidium and Giardia

G Certad, E Viscogliosi, M Chabé, SM Cacciò - Trends in Parasitology, 2017 - cell.com
Intestinal protozoa are important etiological agents of diarrhea, particularly in children, yet
the public health risk they pose is often neglected. Results from the Global Enteric …