Endogenous and exogenous neurotoxins are important factors leading to
neurodegenerative diseases. In the 1980s, the discovery that 1-methyl-4-phenyl-1, 2, 3, 6 …

Major depressive disorder (MDD) and bipolar disorder (BD) are the most common mood
disorders. They are etiologically related, but clinically distinct psychiatric illnesses. Their …

A highly facile, straightforward synthesis of 1-(3-indolyl)-tetrahydroisoquinolines was
developed using either simple copper or iron catalysts. N-protected and unprotected …

Current diagnostic options for Parkinson's disease are very limited and primarily based on
characteristic clinical symptoms. Thus, there are urgent needs for reliable biomarkers that …

Recent research is leading to an ever-increasing range of investigative approaches whose
aim is to achieve effective neuroprotective or neurorestorative treatment for individuals …

In the human brain, isoquinolines are synthesized from catecholamines, β-
phenylethylamine, and indoleamines, and their involvement in the pathogenesis of …

The development of one-pot, multi-component and transition-metal-catalyst free synthetic
protocol for N-heterocycles is a green and sustainable approach. The solvent plays a critical …

Salsolinol (SAL) is an endogenous neurotoxin identified as a potential aetiological factor in
Parkinson's disease (PD). Its neurotoxicity through apoptosis induction and oxidative stress …

Abstract The finding that 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) caused
parkinsonism in human stimulated search for neurotoxins as a pathogenic factor for …

The goal of this dissertation work was to (1) determine the distribution of several
tetrahydroisoquinoline (TIQ) derivatives in rodent, normal human and Parkinson disease …