Kinesin superfamily motor proteins and intracellular transport

N Hirokawa, Y Noda, Y Tanaka, S Niwa - Nature reviews Molecular cell …, 2009 - nature.com
Intracellular transport is fundamental for cellular function, survival and morphogenesis.
Kinesin superfamily proteins (also known as KIFs) are important molecular motors that …

[HTML][HTML] Forces in tissue morphogenesis and patterning

CP Heisenberg, Y Bellaïche - Cell, 2013 - cell.com
During development, mechanical forces cause changes in size, shape, number, position,
and gene expression of cells. They are therefore integral to any morphogenetic processes …

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays

A Chen, S Liao, M Cheng, K Ma, L Wu, Y Lai, X Qiu… - Cell, 2022 - cell.com
Spatially resolved transcriptomic technologies are promising tools to study complex
biological processes such as mammalian embryogenesis. However, the imbalance between …

[HTML][HTML] Brain lateralization: a comparative perspective

O Güntürkün, F Ströckens… - Physiological …, 2020 - journals.physiology.org
Comparative studies on brain asymmetry date back to the 19th century but then largely
disappeared due to the assumption that lateralization is uniquely human. Since the …

[HTML][HTML] Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease

N Hirokawa, S Niwa, Y Tanaka - Neuron, 2010 - cell.com
The kinesin, dynein, and myosin superfamily molecular motors have fundamental roles in
neuronal function, plasticity, morphogenesis, and survival by transporting cargos such as …

Overview of structure and function of mammalian cilia

P Satir, ST Christensen - Annu. Rev. Physiol., 2007 - annualreviews.org
Cilia are membrane-bounded, centriole-derived projections from the cell surface that contain
a microtubule cytoskeleton, the ciliary axoneme, surrounded by a ciliary membrane …

The ciliopathies: an emerging class of human genetic disorders

JL Badano, N Mitsuma, PL Beales… - Annu. Rev. Genomics …, 2006 - annualreviews.org
Cilia and flagella are ancient, evolutionarily conserved organelles that project from cell
surfaces to perform diverse biological roles, including whole-cell locomotion; movement of …

Mechanisms of mechanotransduction

AW Orr, BP Helmke, BR Blackman, MA Schwartz - Developmental cell, 2006 - cell.com
Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces
regulate a large array of physiological processes, and dysregulation of mechanical …

New neurons follow the flow of cerebrospinal fluid in the adult brain

K Sawamoto, H Wichterle, O Gonzalez-Perez… - Science, 2006 - science.org
In the adult brain, neuroblasts born in the subventricular zone migrate from the walls of the
lateral ventricles to the olfactory bulb. How do these cells orient over such a long distance …

Primary cilia are not calcium-responsive mechanosensors

M Delling, AA Indzhykulian, X Liu, Y Li, T **e, DP Corey… - Nature, 2016 - nature.com
Primary cilia are solitary, generally non-motile, hair-like protrusions that extend from the
surface of cells between cell divisions. Their antenna-like structure leads naturally to the …