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Review of cellular mechanotransduction
Living cells and tissues experience physical forces and chemical stimuli in the human body.
The process of converting mechanical forces into biochemical activities and gene …
The process of converting mechanical forces into biochemical activities and gene …
Cytoskeletal prestress: The cellular hallmark in mechanobiology and mechanomedicine
Increasing evidence demonstrates that mechanical forces, in addition to soluble molecules,
impact cell and tissue functions in physiology and diseases. How living cells integrate …
impact cell and tissue functions in physiology and diseases. How living cells integrate …
Single-molecule characterization of subtype-specific β1 integrin mechanics
Although integrins are known to be mechanosensitive and to possess many subtypes that
have distinct physiological roles, single molecule studies of force exertion have thus far …
have distinct physiological roles, single molecule studies of force exertion have thus far …
Unraveling the Dual-Stretch-Mode Impact on Tension Gauge Tethers' Mechanical Stability
Tension gauge tethers (TGTs), short DNA segments serving as extracellular tension
sensors, are instrumental in assessing the tension dynamics in mechanotransduction. These …
sensors, are instrumental in assessing the tension dynamics in mechanotransduction. These …
Regulation and dynamics of force transmission at individual cell-matrix adhesion bonds
Integrin-based adhesion complexes link the cytoskeleton to the extracellular matrix (ECM)
and are central to the construction of multicellular animal tissues. How biological function …
and are central to the construction of multicellular animal tissues. How biological function …
Tension gauge tethers as tension threshold and duration sensors
Mechanotransduction, the process by which cells respond to tension transmitted through
various supramolecular linkages, is important for understanding cellular behavior. Tension …
various supramolecular linkages, is important for understanding cellular behavior. Tension …
Physically active bioreactors for tissue engineering applications
Tissue engineering (TE) is a strongly expanding research area. TE approaches require
biocompatible scaffolds, cells, and different applied stimuli, which altogether mimic the …
biocompatible scaffolds, cells, and different applied stimuli, which altogether mimic the …
Super-resolved visualization of single DNA-based tension sensors in cell adhesion
Cell-extracellular matrix sensing plays a crucial role in cellular behavior and leads to the
formation of a macromolecular protein complex called the focal adhesion. Despite their …
formation of a macromolecular protein complex called the focal adhesion. Despite their …
All-covalent nuclease-resistant and hydrogel-tethered DNA hairpin probes map pN cell traction forces
Cells sense and respond to the physical properties of their environment through receptor-
mediated signaling, a process known as mechanotransduction, which can modulate critical …
mediated signaling, a process known as mechanotransduction, which can modulate critical …
EGFR activation attenuates the mechanical threshold for integrin tension and focal adhesion formation
Mechanical forces, growth factors and the extracellular matrix all play crucial roles in cell
adhesion. To understand how epidermal growth factor receptor (EGFR) impacts the …
adhesion. To understand how epidermal growth factor receptor (EGFR) impacts the …