The flavivirus NS2B–NS3 protease–helicase as a target for antiviral drug development
The flavivirus NS3 protein is associated with the endoplasmic reticulum membrane via its
close interaction with the central hydrophilic region of the NS2B integral membrane protein …
close interaction with the central hydrophilic region of the NS2B integral membrane protein …
Anti-dengue therapeutic potential of Tinospora cordifolia and its bioactives
Ethnopharmacological relevance Dengue is one of the most prevalent mosquito-borne viral
infections. Moreover, due to the absence of appropriate curative and preventive measures …
infections. Moreover, due to the absence of appropriate curative and preventive measures …
Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction
Recent outbreaks of Zika virus (ZIKV) highlight an urgent need for therapeutics. The
protease complex NS2B-NS3 plays essential roles during flaviviral polyprotein processing …
protease complex NS2B-NS3 plays essential roles during flaviviral polyprotein processing …
Biochemistry and medicinal chemistry of the dengue virus protease
Dengue virus is the pathogenic principle behind several medical conditions. The most
common disease caused by this virus is dengue fever, characterized by high fever and flu …
common disease caused by this virus is dengue fever, characterized by high fever and flu …
Molecular pathogenesis of Japanese encephalitis and possible therapeutic strategies
Japanese encephalitis virus (JEV), a single-stranded, enveloped RNA virus, is a health
concern across Asian countries, associated with severe neurological disorders, especially in …
concern across Asian countries, associated with severe neurological disorders, especially in …
Allosteric inhibition of the NS2B-NS3 protease from dengue virus
Dengue virus is the flavivirus that causes dengue fever, dengue hemorrhagic disease, and
dengue shock syndrome, which are currently increasing in incidence worldwide. Dengue …
dengue shock syndrome, which are currently increasing in incidence worldwide. Dengue …
Antiviral agents against flavivirus protease: prospect and future direction
Flaviviruses cause a significant amount of mortality and morbidity, especially in regions
where they are endemic. A recent example is the outbreak of Zika virus throughout the …
where they are endemic. A recent example is the outbreak of Zika virus throughout the …
An in-silico investigation of phytochemicals as antiviral agents against dengue fever
CN Powers, WN Setzer - Combinatorial chemistry & high …, 2016 - ingentaconnect.com
A virtual screening analysis of our library of phytochemical structures with dengue virus
protein targets has been carried out using a molecular docking approach. A total of 2194 …
protein targets has been carried out using a molecular docking approach. A total of 2194 …
Binding of low molecular weight inhibitors promotes large conformational changes in the dengue virus NS2B-NS3 protease: fold analysis by pseudocontact shifts
L De La Cruz, THD Nguyen, K Ozawa… - Journal of the …, 2011 - ACS Publications
The two-component dengue virus NS2B-NS3 protease (DEN NS2B-NS3pro) is an
established drug target, but inhibitor design is hampered by the lack of a crystal structure of …
established drug target, but inhibitor design is hampered by the lack of a crystal structure of …
Characterization of pH-induced conformational changes in recombinant DENV NS2B-NS3pro
The increasing frequency of Dengue is a cause of severe epidemics and therefore demands
strategies for effective prevention, diagnosis, and treatment. DENV-protease is being …
strategies for effective prevention, diagnosis, and treatment. DENV-protease is being …