Epithelial–mesenchymal transition (EMT) is a program wherein epithelial cells lose their
junctions and polarity while acquiring mesenchymal properties and invasive ability …

Pancreatic ductal adenocarcinoma (PDAC) is among the dangerous human cancers, is the
10th highly prevalent cancer, and the fourth sole cause of cancer-related mortality in the …

Breast cancer is the leading cause of death among women worldwide. Despite the recent
treatment options like surgery, chemotherapy etc. the lethality of breast cancer is alarming …

The transcription factor Prdm16 functions as a potent suppressor of transforming growth
factor-beta (TGF-β) signaling, whose inactivation is deemed essential to the progression of …

Abstract Interferon regulatory factor 7 (IRF7) is widely studied in inflammatory models. Its
effects on malignant progression have been documented mainly from the perspective of the …

Lung adenocarcinoma (LUAD) relies on dysregulated gene expression to sustain its infinite
growth and progression. Emerging evidence indicates that aberrant transcriptional program …

Background Deacetylation of histones by histone deacetylase 3 (HDAC3) acts importantly in
modulating apoptosis, DNA damage and cellular progression. Herein, we aimed to unravel …

Reprogrammed glucose metabolism is essential for tumor initiation and development,
especially for pancreatic ductal adenocarcinoma (PDAC). Most cancer cells rely on aerobic …

A major goal of cancer genomics is to identify all genes that play critical roles in
carcinogenesis. Most approaches focused on genes positively selected for mutations that …

A long-standing question in the pancreatic ductal adenocarcinoma (PDAC) field has been
whether alternative genetic alterations could substitute for oncogenic KRAS mutations in …