T follicular helper cell biology: a decade of discovery and diseases
S Crotty - Immunity, 2019 - cell.com
Hel** B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …
B cell responses: cell interaction dynamics and decisions
JG Cyster, CDC Allen - Cell, 2019 - cell.com
B cells and the antibodies they produce have a deeply penetrating influence on human
physiology. Here, we review current understanding of how B cell responses are initiated; the …
physiology. Here, we review current understanding of how B cell responses are initiated; the …
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19
Pediatric coronavirus disease 2019 (COVID-19) after SARS-CoV-2 infection is associated
with fewer hospitalizations and often milder disease than in adults. A subset of children …
with fewer hospitalizations and often milder disease than in adults. A subset of children …
[HTML][HTML] Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals
Vaccine-mediated immunity often relies on the generation of protective antibodies and
memory B cells, which commonly stem from germinal center (GC) reactions. An in-depth …
memory B cells, which commonly stem from germinal center (GC) reactions. An in-depth …
Functional Th1-oriented T follicular helper cells that infiltrate human breast cancer promote effective adaptive immunity
G Noël, ML Fontsa, S Garaud… - The Journal of …, 2021 - Am Soc Clin Investig
We previously demonstrated that tumor-infiltrating lymphocytes (TIL) in human breast cancer
sometimes form organized tertiary lymphoid structures (TLS) characterized by CXCL13 …
sometimes form organized tertiary lymphoid structures (TLS) characterized by CXCL13 …
[HTML][HTML] Inflammation and immunity in IPF pathogenesis and treatment
P Heukels, CC Moor, JH Von der Thüsen… - Respiratory …, 2019 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive, and ultimately fatal, chronic interstitial
lung disease characterized by enhanced extracellular matrix deposition. Repetitive alveolar …
lung disease characterized by enhanced extracellular matrix deposition. Repetitive alveolar …
Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus
C Law, VS Wacleche, Y Cao, A Pillai, J Sowerby… - Nature, 2024 - nature.com
Systemic lupus erythematosus (SLE) is prototypical autoimmune disease driven by
pathological T cell–B cell interactions,. Expansion of T follicular helper (TFH) and T …
pathological T cell–B cell interactions,. Expansion of T follicular helper (TFH) and T …
[HTML][HTML] TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures
The immune checkpoint receptor PD-1 on T follicular helper (Tfh) cells promotes Tfh: B cell
interactions and appropriate positioning within tissues. Here, we examined the impact of …
interactions and appropriate positioning within tissues. Here, we examined the impact of …
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine
Abstract Anti-programmed death-1 (anti-PD-1) immunotherapy reinvigorates CD8 T cell
responses in patients with cancer but PD-1 is also expressed by other immune cells …
responses in patients with cancer but PD-1 is also expressed by other immune cells …
Early B cell changes predict autoimmunity following combination immune checkpoint blockade
Combination checkpoint blockade (CCB) targeting inhibitory CTLA4 and PD1 receptors
holds promise for cancer therapy. Immune-related adverse events (IRAEs) remain a major …
holds promise for cancer therapy. Immune-related adverse events (IRAEs) remain a major …