Crystal engineering of pharmaceutical cocrystals in the discovery and development of improved drugs

G Bolla, B Sarma, AK Nangia - Chemical reviews, 2022 - ACS Publications
The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

Tinkering with mechanochemical tools for scale up

JF Reynes, V Isoni, F García - … Chemie International Edition, 2023 - Wiley Online Library
Mechanochemistry provides an environmentally benign platform to develop more
sustainable chemical processes by limiting raw materials, energy use, and waste generation …

Synthesis of ternary cocrystals, salts, and hydrates of acefylline with enhanced dissolution and high permeability

S Allu, A Garai, VV Chernyshev… - Crystal Growth & …, 2022 - ACS Publications
Acefylline (ACF) is a stimulant xanthine derivative drug, which is formulated as a piperazine
salt for the treatment of bronchial asthma. ACF falls under BCS class IV category of low …

The unique opportunities of mechanosynthesis in green and scalable fabrication of metal–organic frameworks

F Afshariazar, A Morsali - Journal of Materials Chemistry A, 2022 - pubs.rsc.org
Due to the fascinating molecular structure of MOFs and their widespread practical use in
various industrial applications, great attention has focused on the development of …

Fast and scalable solvent-free access to Lappert's heavier tetrylenes E {N (SiMe 3) 2} 2 (E= Ge, Sn, Pb) and ECl {N (SiMe 3) 2}(E= Ge, Sn)

JA Cabeza, JF Reynes, F García, P García-Álvarez… - Chemical …, 2023 - pubs.rsc.org
Iconic Lappert's heavier tetrylenes E {N (SiMe3) 2} 2 (E= Ge (1), Sn (2), Pb (3)) have been
efficiently prepared from GeCl2·(1, 4-dioxane), SnCl2 or PbCl2 and Li {N (SiMe3) 2} via a …

Mechanochemical synthesis of cocrystal: From mechanism to application

Y **ao, C Wu, X Hu, K Chen, L Qi, P Cui… - Crystal Growth & …, 2023 - ACS Publications
Cocrystal engineering is gaining interest across various disciplines since it can effectively
tune the properties of solid substances via noncovalent synthesis by introducing new …

Utilizing “Latent” Carbon: Repositioning Hydrogen‐Bonded Synthons and Assemblies via Halogen Bonding to π‐Systems

J Vainauskas, A Wahrhaftig‐Lewis… - Angewandte Chemie …, 2024 - Wiley Online Library
Molecules bearing carboxylic acid, amide, and hydroxyl groups are ubiquitous in crystal
engineering, where robust hydrogen‐bonded synthons centred on these functionalities …

Temperature-Responsive Cocrystal Engineering for Efficacious Delivery of Poorly Water-Soluble Herbicide

Y **ao, C Wu, S Feng, K Chen, L Zhou… - Crystal Growth & …, 2023 - ACS Publications
Addressing the challenges posed by the low water solubility of numerous herbicides is
crucial as it directly affects their bioavailability and efficacy. This limited solubility often …

Supramolecular self-assembly strategy for the enhanced solubility/dissolution rate and anti-cancer efficacy of osimertinib: Insights from multi-component crystals to …

X Liang, Y Wu, Y Deng, X Zeng, S Shan, Y Jiang… - Chemical Engineering …, 2024 - Elsevier
Multi-component crystal based on supramolecular self-assembly is an effective strategy to
modify the physicochemical properties of poorly water-soluble drugs. In this study, eight …

Spin in Organic Cocrystals

C Zhang, X Wang, Y Li, Y Sun… - Chemistry–A European …, 2023 - Wiley Online Library
Organic spintronics has caused a huge revolution in creating highly efficient low‐power
circuits. Spin manipulation in organic cocrystals has become a promising strategy to uncover …