Crystal engineering of pharmaceutical cocrystals in the discovery and development of improved drugs
The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …
reactions in the solid state. A broad chemical definition of crystal engineering was published …
Tinkering with mechanochemical tools for scale up
Mechanochemistry provides an environmentally benign platform to develop more
sustainable chemical processes by limiting raw materials, energy use, and waste generation …
sustainable chemical processes by limiting raw materials, energy use, and waste generation …
Synthesis of ternary cocrystals, salts, and hydrates of acefylline with enhanced dissolution and high permeability
Acefylline (ACF) is a stimulant xanthine derivative drug, which is formulated as a piperazine
salt for the treatment of bronchial asthma. ACF falls under BCS class IV category of low …
salt for the treatment of bronchial asthma. ACF falls under BCS class IV category of low …
The unique opportunities of mechanosynthesis in green and scalable fabrication of metal–organic frameworks
Due to the fascinating molecular structure of MOFs and their widespread practical use in
various industrial applications, great attention has focused on the development of …
various industrial applications, great attention has focused on the development of …
Fast and scalable solvent-free access to Lappert's heavier tetrylenes E {N (SiMe 3) 2} 2 (E= Ge, Sn, Pb) and ECl {N (SiMe 3) 2}(E= Ge, Sn)
Iconic Lappert's heavier tetrylenes E {N (SiMe3) 2} 2 (E= Ge (1), Sn (2), Pb (3)) have been
efficiently prepared from GeCl2·(1, 4-dioxane), SnCl2 or PbCl2 and Li {N (SiMe3) 2} via a …
efficiently prepared from GeCl2·(1, 4-dioxane), SnCl2 or PbCl2 and Li {N (SiMe3) 2} via a …
Mechanochemical synthesis of cocrystal: From mechanism to application
Y **ao, C Wu, X Hu, K Chen, L Qi, P Cui… - Crystal Growth & …, 2023 - ACS Publications
Cocrystal engineering is gaining interest across various disciplines since it can effectively
tune the properties of solid substances via noncovalent synthesis by introducing new …
tune the properties of solid substances via noncovalent synthesis by introducing new …
Utilizing “Latent” Carbon: Repositioning Hydrogen‐Bonded Synthons and Assemblies via Halogen Bonding to π‐Systems
J Vainauskas, A Wahrhaftig‐Lewis… - Angewandte Chemie …, 2024 - Wiley Online Library
Molecules bearing carboxylic acid, amide, and hydroxyl groups are ubiquitous in crystal
engineering, where robust hydrogen‐bonded synthons centred on these functionalities …
engineering, where robust hydrogen‐bonded synthons centred on these functionalities …
Temperature-Responsive Cocrystal Engineering for Efficacious Delivery of Poorly Water-Soluble Herbicide
Y **ao, C Wu, S Feng, K Chen, L Zhou… - Crystal Growth & …, 2023 - ACS Publications
Addressing the challenges posed by the low water solubility of numerous herbicides is
crucial as it directly affects their bioavailability and efficacy. This limited solubility often …
crucial as it directly affects their bioavailability and efficacy. This limited solubility often …
Supramolecular self-assembly strategy for the enhanced solubility/dissolution rate and anti-cancer efficacy of osimertinib: Insights from multi-component crystals to …
Multi-component crystal based on supramolecular self-assembly is an effective strategy to
modify the physicochemical properties of poorly water-soluble drugs. In this study, eight …
modify the physicochemical properties of poorly water-soluble drugs. In this study, eight …
Spin in Organic Cocrystals
Organic spintronics has caused a huge revolution in creating highly efficient low‐power
circuits. Spin manipulation in organic cocrystals has become a promising strategy to uncover …
circuits. Spin manipulation in organic cocrystals has become a promising strategy to uncover …