Pharmacological approaches to the prevention of type 2 diabetes mellitus

P Majety, FA Lozada Orquera, D Edem… - Frontiers in …, 2023 - frontiersin.org
About 1 in 10 adults worldwide are estimated to have diabetes mellitus. They are at risk of
develo** life-threatening complications resulting in reduced quality of life, increased …

Obesity, type 2 diabetes, and testosterone in ageing men

G Wittert, M Grossmann - Reviews in Endocrine and Metabolic Disorders, 2022 - Springer
In the absence of obesity, adverse lifestyle behaviours, and use of medication such as
opioids serum testosterone concentrations decrease by only a minimal amount at least until …

Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year …

G Wittert, K Bracken, KP Robledo… - The lancet Diabetes & …, 2021 - thelancet.com
Background Men who are overweight or obese frequently have low serum testosterone
concentrations, which are associated with increased risk of type 2 diabetes. We aimed to …

Testosterone therapy in men with hypogonadism prevents progression from prediabetes to type 2 diabetes: eight-year data from a registry study

A Yassin, A Haider, KS Haider, M Caliber… - Diabetes …, 2019 - diabetesjournals.org
OBJECTIVE Type 2 diabetes (T2D) is a public health threat. Prediabetes represents a
window of opportunity for intervention to prevent T2D. Men with T2D and prediabetes often …

Sex hormones, obesity and type 2 diabetes: is there a link?

A Gambineri, C Pelusi - Endocrine connections, 2019 - ec.bioscientifica.com
An imbalance in sex hormones has an important impact on type 2 diabetes (T2DM) mainly
through the involvement of visceral adipose tissue. Androgens have an interesting sex …

Late‐onset hypogonadism: metabolic impact

M Grossmann, M Ng Tang Fui, AS Cheung - Andrology, 2020 - Wiley Online Library
Background Obesity and dysglycemia (comprising insulin resistance, the metabolic
syndrome and type 2 diabetes), that is diabesity, are associated with reduced circulating …

Associations of thyroid feedback quantile-based index with diabetes in euthyroid adults in the United States and China

H Wan, G Yu, Y He, S Liu, X Chen, Y Jiang… - Annals of …, 2024 - Taylor & Francis
Background We aimed to investigate the associations between thyroid hormone sensitivity
indices and diabetes in euthyroid adults in the United States and China. Methods 2296 …

Mediation analysis of the testosterone treatment effect to prevent type 2 diabetes in the Testosterone for Prevention of Type 2 Diabetes Mellitus trial

KP Robledo, IC Marschner… - European journal of …, 2023 - academic.oup.com
Objective To determine if testosterone treatment effect on glycaemia is mediated through
changes in total fat mass, abdominal fat mass, skeletal muscle mass, non-dominant hand …

Testosterone therapy and cardiovascular diseases

A Cittadini, AM Isidori, A Salzano - Cardiovascular research, 2022 - academic.oup.com
Since it was first synthesized in 1935, testosterone (T) has been viewed as the mythical
Fountain of Youth, promising rejuvenation, restoring sexual appetites, growing stronger …

Weight loss more than glycemic control may improve testosterone in obese type 2 diabetes mellitus men with hypogonadism

VA Giagulli, M Castellana, MD Carbone, C Pelusi… - …, 2020 - Wiley Online Library
Background Functional hypogonadism is a common disorder among patients with obesity
and type 2 diabetes mellitus and could be managed by first treating the underlying causes …