Bioactive materials are a special class of biomaterials that can react in vivo to induce a
biological response or regulate biological functions, thus achieving a better curative effect …

The great clinical success of cisplatin and its derivatives has convinced people that metal
complexes could play a more significant role in human cancer therapy. However, targeting …

Glutathione (GSH), the main redox buffer, has long been recognized as a pivotal modulator
of tumor initiation, progression and metastasis. It is also implicated in the resistance of …

Diabetic nephropathy (DN) is thought to be the major cause of end-stage renal disease. Due
to its complicated pathogenesis and the low efficacy of DN treatment, a deep understanding …

Many epithelial tumors grow in the vicinity of or metastasize to adipose tissue. As tumors
develop, crosstalk between adipose tissue and cancer cells leads to changes in adipocyte …

Ferroptosis, an iron-dependent cell death, plays a crucial role in the pathology of
Alzheimer's disease (AD). Several characteristics of AD, including excessive iron …

Ferroptosis, an unusual non-apoptotic cell death caused by the iron-dependent
accumulation of lipid peroxide, enables the flexible design of an antitumor platform …

Ferroptosis is a novel type of programmed cell death, characterized by a dysregulated iron
metabolism and accumulation of lipid peroxides. It features the alteration of mitochondria …

Reactive oxygen species (ROS) play a crucial role in physiological and pathological
processes, emerging as a therapeutic target in cancer. Owing to the high concentration of …

Encouraged by the dependence of drug-resistant, metastatic cancers on GPX4, we
examined biophysical mechanisms of GPX4 inhibition, which revealed an unexpected …