Autophagy orchestrates the crosstalk between cells and organs

K Piletic, G Alsaleh, AK Simon - EMBO reports, 2023 - embopress.org
Over the recent years, it has become apparent that a deeper understanding of cell‐to‐cell
and organ‐to‐organ communication is necessary to fully comprehend both homeostatic and …

[HTML][HTML] Secretome analysis using Affinity Proteomics and Immunoassays: a focus on Tumor Biology

VM Beutgen, V Shinkevich, J Pörschke… - Molecular & Cellular …, 2024 - Elsevier
The study of the cellular secretome using proteomic techniques continues to capture the
attention of the research community across a broad range of topics in biomedical research …

[HTML][HTML] Triphenyl phosphate proved more potent than its metabolite diphenyl phosphate in inducing hepatic insulin resistance through endoplasmic reticulum stress

J Yue, X Sun, X Duan, C Sun, H Chen, H Sun… - Environment …, 2023 - Elsevier
Triphenyl phosphate (TPHP) is a widely used flame retardant and plasticizer and has been
detected extensively in environmental media, wildlife and human bodies. Several …

[HTML][HTML] PSMA2 knockdown impacts expression of proteins involved in immune and cellular stress responses in human lung cells

M Rashid, S Lorzadeh, A Gao, S Ghavami… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Proteasome subunit alpha type-2 (PSMA2) is a critical component of the 20S proteasome,
which is the core particle of the 26S proteasome complex and is involved in cellular protein …

Communicator Extraordinaire: Extracellular vesicles in the Tumor Microenvironment are essential local and long-Distance mediators of Cancer Metastasis

MI Mitchell, O Loudig - Biomedicines, 2023 - mdpi.com
Human tumors are increasingly being described as a complex “ecosystem”, that includes
many different cell types, secreted growth factors, extracellular matrix (ECM) components …

The Dual Role of Sulforaphane-Induced Cellular Stress—A Systems Biological Study

M Holczer, B Besze, A Lehel, O Kapuy - International Journal of …, 2024 - mdpi.com
The endoplasmic reticulum (ER) plays a crucial role in cellular homeostasis. When ER
stress is generated, an autophagic self-digestive process is activated to promote cell …

Molecular mechanisms of secretory autophagy and its potential role in diseases

Q Li, G Peng, H Liu, L Wang, R Lu, L Li - Life Sciences, 2024 - Elsevier
Autophagy is a cellular degradation system that recycles or degrades damaged organelles,
viral particles, and aggregated proteins through the lysosomal pathway. Autophagy plays an …

[HTML][HTML] Autophagy-mediated ferroptosis involved in nickel-induced nephrotoxicity in the mice

Q Yang, Z Zuo, Y Zeng, Y Ouyang, H Cui… - Ecotoxicology and …, 2023 - Elsevier
Nickel, as a widely polluted metal, has been shown nephrotoxicity. Ferroptosis is a new type
of cell death driven by iron-dependent lipid peroxidation. Our study found that nickel chloride …

Exosome-Based Macromolecular neurotherapeutic drug delivery approaches in overcoming the Blood-Brain barrier for treating brain disorders

K Yadav, R Vijayalakshmi, KK Sahu, P Sure… - European Journal of …, 2024 - Elsevier
Delivering drugs to the brain is a complex challenge in medical research, particularly for
disorders like Alzheimer's and Parkinson's. The blood–brain barrier restricts the entry of …

Extracellular vesicles derived from stressed beta cells mediate monocyte activation and contribute to islet inflammation

MC Dekkers, JM Lambooij, X Pu… - Frontiers in …, 2024 - frontiersin.org
Objective Beta cell destruction in type 1 diabetes (T1D) results from the combined effect of
inflammation and recurrent autoimmunity. In recent years, the role played by beta cells in the …