Fluid biomarkers for synaptic dysfunction and loss

E Camporesi, J Nilsson, A Brinkmalm… - Biomarker …, 2020 - journals.sagepub.com
Synapses are the site for brain communication where information is transmitted between
neurons and stored for memory formation. Synaptic degeneration is a global and early …

Phosphoinositides: regulators of nervous system function in health and disease

P Raghu, A Joseph, H Krishnan, P Singh… - Frontiers in molecular …, 2019 - frontiersin.org
Phosphoinositides, the seven phosphorylated derivatives of phosphatidylinositol have
emerged as regulators of key sub-cellular processes such as membrane transport …

A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1

L Hai, DC Hoffmann, RJ Wagener, DD Azorin… - Nature …, 2024 - nature.com
Tumor microtubes (TMs) connect glioma cells to a network with considerable relevance for
tumor progression and therapy resistance. However, the determination of TM …

Early nerve fibre regeneration in individuals with type 1 diabetes after simultaneous pancreas and kidney transplantation

S Azmi, M Jeziorska, M Ferdousi, IN Petropoulos… - Diabetologia, 2019 - Springer
Aims/hypothesis The study aimed to assess the impact on neuropathy of simultaneous
pancreas and kidney transplantation (SPK) in individuals with type 1 diabetes. Methods This …

MARCKS and MARCKS-like proteins in development and regeneration

M El Amri, U Fitzgerald, G Schlosser - Journal of biomedical science, 2018 - Springer
Abstract Background The Myristoylated Alanine-Rich C-kinase Substrate (MARCKS) and
MARCKS-like protein 1 (MARCKSL1) have a wide range of functions, ranging from roles in …

A neuromuscular perspective of sarcopenia pathogenesis: deciphering the signaling pathways involved

A Moreira-Pais, R Ferreira, PA Oliveira, JA Duarte - Geroscience, 2022 - Springer
The escalation of life expectancy is accompanied by an increase in the prevalence of age-
related conditions, such as sarcopenia. Sarcopenia, a muscle condition defined by low …

CSF GAP-43 as a biomarker of synaptic dysfunction is associated with tau pathology in Alzheimer's disease

Q Qiang, L Skudder-Hill, T Toyota, W Wei, H Adachi - Scientific Reports, 2022 - nature.com
To test whether cerebrospinal fluid (CSF) growth-associated protein 43 (GAP-43)
concentration is elevated in Alzheimer's disease (AD) dementia and its associations with …

Antidepressant effects of the traditional Chinese herbal formula **ao-Yao-San and its bioactive ingredients

YT Wang, XL Wang, ZZ Wang, L Lei, D Hu, Y Zhang - Phytomedicine, 2023 - Elsevier
Background Depression is one of the most debilitating and severe psychiatric disorders and
a serious public health concern. Currently, many treatments are indicated for depression …

Proteomics of autism and Alzheimer's mouse models reveal common alterations in mTOR signaling pathway

S Mencer, M Kartawy, F Lendenfeld, H Soluh… - Translational …, 2021 - nature.com
Autism spectrum disorder (ASD) and Alzheimer's disease (AD) are two different neurological
disorders that share common clinical features, such as language impairment, executive …

Genome‐wide association study of word reading: Overlap with risk genes for neurodevelopmental disorders

KM Price, KG Wigg, Y Feng, K Blokland… - Genes, Brain and …, 2020 - Wiley Online Library
Reading disabilities (RD) are the most common neurocognitive disorder, affecting 5% to
17% of children in North America. These children often have comorbid neurodevelopmental …