The role of microRNA-21 (miR-21) in pathogenesis, diagnosis, and prognosis of gastrointestinal cancers: A review

BF Far, K Vakili, M Fathi, S Yaghoobpoor, M Bhia… - Life sciences, 2023 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNAs regulating the expression of several
target genes. miRNAs play a significant role in cancer biology, as they can downregulate …

The promising role of miR-21 as a cancer biomarker and its importance in RNA-based therapeutics

D Bautista-Sánchez, C Arriaga-Canon… - … therapy Nucleic acids, 2020 - cell.com
MicroRNAs are small noncoding transcripts that posttranscriptionally regulate gene
expression via base-pairing complementarity. Their role in cancer can be related to tumor …

[HTML][HTML] miRNA targets: from prediction tools to experimental validation

G Riolo, S Cantara, C Marzocchi, C Ricci - Methods and protocols, 2020 - mdpi.com
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression in both animals
and plants. By pairing to microRNA responsive elements (mREs) on target mRNAs, miRNAs …

Dissecting the functional role of microRNA 21 in osteosarcoma

D Sekar, P Mani, M Biruntha, P Sivagurunathan… - Cancer gene …, 2019 - nature.com
Osteosarcoma (OS) is considered to be a malignant bone tumour that mainly affects the long
bones, but it is also involved in other bones of the body. Currently, surgery and …

Emerging role of microRNA-21 in cancer

YH Feng, CJ Tsao - Biomedical reports, 2016 - spandidos-publications.com
MicroRNAs (miRs) are a class of single-stranded RNA molecules of 15–27 nucleotides in
length that regulate gene expression at the post-translational level. miR-21 is one of the …

Micro-RNA: The darkhorse of cancer

M Budakoti, AS Panwar, D Molpa, RK Singh… - Cellular signalling, 2021 - Elsevier
The discovery of micro RNAs (miRNA) in cancer has opened up new vistas for researchers
in recent years. Micro RNAs area set of small, endogenous, highly conserved, non-coding …

Breast cancer stem-like cells in drug resistance: a review of mechanisms and novel therapeutic strategies to overcome drug resistance

T Saha, KE Lukong - Frontiers in oncology, 2022 - frontiersin.org
Breast cancer is the most frequent type of malignancy in women worldwide, and drug
resistance to the available systemic therapies remains a major challenge. At the molecular …

Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers

R Hamam, D Hamam, KA Alsaleh, M Kassem… - Cell death & …, 2017 - nature.com
Effective management of breast cancer depends on early diagnosis and proper monitoring
of patients' response to therapy. However, these goals are difficult to achieve because of the …

Therapeutic targeting of microRNAs: current status and future challenges

Z Li, TM Rana - Nature reviews Drug discovery, 2014 - nature.com
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that have crucial
roles in regulating gene expression. Increasing evidence supports a role for miRNAs in …

MicroRNA as an important target for anticancer drug development

Z Fu, L Wang, S Li, F Chen, KKW Au-Yeung… - Frontiers in …, 2021 - frontiersin.org
Cancer has become the second greatest cause of death worldwide. Although there are
several different classes of anticancer drugs that are available in clinic, some tough issues …