Conventional MR images are qualitative, and their signal intensity is dependent on several
complementary contrast mechanisms that are manipulated by the MR hardware and …

Purpose β-Thalassemia is an inherited blood disorder characterized by reduced or no
production of adult hemoglobin. Systematic identification of the burden of β-thalassemia with …

Fibrogenesis is part of a normal protective response to tissue injury that can become
irreversible and progressive, leading to fatal diseases. Senescent cells are a main driver of …

Iron and ascorbic acid (vitamin C) are essential nutrients for the normal growth and
development of humans, and their deficiency can result in serious diseases. Their …

Iron is essential for all organisms and cells. Diseases of iron imbalance affect billions of
patients, including those with iron overload and other forms of iron toxicity. Excess iron load …

Hepatic iron overload is the abnormal and excessive intracellular accumulation of iron in
hepatocytes, Kupffer cells, or both hepatocytes and Kupffer cells, primarily as ferritin …

The hormone erythroferrone (ERFE) is produced by erythroid cells in response to
hemorrhage, hypoxia, or other erythropoietic stimuli, and it suppresses the hepatic …

Deferiprone (L1) was originally designed, synthesised and screened in vitro and in vivo in
1981 by Kontoghiorghes GJ following his discovery of the novel alpha-ketohydroxypyridine …

Failure of pubertal growth, delay or absence of sexual development, infertility and sexual
dysfunction due to hypogonadism and defective spermatogenesis are frequent and well …

The need for preparing new strategies for the design of emergency drug therapies against
COVID-19 and similar diseases in the future is rather urgent, considering the high rate of …