Mathematical modeling is an essential approach for the understanding of complex
multicellular behaviors in tissue morphogenesis. Here, we review the cellular Potts model …

Synthetic biology efforts began in simple single-cell systems, which were relatively easy to
manipulate genetically (Cameron et al., 2014). The field grew exponentially in the last two …

Murine dermis contains functionally and spatially distinct fibroblast lineages that cease to
proliferate in early postnatal life. Here, we propose a model in which a negative feedback …

Motivation Due to the complexity and heterogeneity of multicellular biological systems,
mathematical models that take into account cell signalling, cell population behaviour and the …

Cellular Potts models are broadly applied across developmental biology and cancer
research. We overcome limitations of the traditional approach, which reinterprets a modified …

Computational models of normal liver function and xenobiotic induced liver damage are
increasingly being used to interpret in vitro and in vivo data and as an approach to the de …

Lumens, liquid-filled cavities surrounded by polarized tissue cells, are elementary units
involved in the morphogenesis of organs. Theoretical modeling and computations, which …

Biliary ducts collect bile from liver lobules, the smallest functional and anatomical units of
liver, and carry it to the gallbladder. Disruptions in this process caused by defective …

In vitro tumor models consisting of cell spheroids are increasingly used for mechanistic
studies and pharmacological testing. However, unless vascularized, the availability of …

Renal cystogenesis is the pathological hallmark of autosomal dominant polycystic kidney
disease, caused by PKD1 and PKD2 mutations. The formation of renal cysts is a common …