Transposable elements (TEs) are insertional mutagens that contribute greatly to the
plasticity of eukaryotic genomes, influencing the evolution and adaptation of species as well …

Transposable elements give rise to interspersed repeats, sequences that comprise most of
our genomes. These mobile DNAs have been historically underappreciated—both because …

Their ability to move within genomes gives transposable elements an intrinsic propensity to
affect genome evolution. Non-long terminal repeat (LTR) retrotransposons—including LINE …

Transposable elements (TEs) or “jum** genes” historically have been disparaged as a
class of “junk DNA” in mammalian genomes (1, 2). The advent of whole genome DNA …

Summary Highly active (ie," hot") long interspersed element-1 (LINE-1 or L1) sequences
comprise the bulk of retrotransposition activity in the human genome; however, the …

The completion of the human genome reference sequence ushered in a new era for the
study and discovery of human transposable elements. It now is undeniable that …

Our genome is a historic record of successive invasions of mobile genetic elements. Like
other eukaryotes, we have evolved mechanisms to limit their propagation and minimize the …

Using high-throughput sequencing, we devised a technique to determine the insertion sites
of virtually all members of the human-specific L1 retrotransposon family in any human …

Characterizing structural variants in the human genome is of great importance, but a
genome wide analysis to detect interspersed repeats has not been done. Thus, the degree …

Transposable elements (TEs) comprise a group of repetitive sequences that bring positive,
negative, as well as neutral effects to the host organism. Earlier considered as “junk DNA,” …