Cell death is an essential phenomenon in normal development and homeostasis, but also
plays a crucial role in various pathologies. Our understanding of the molecular mechanisms …

TNF was originally characterized as an antitumor agent and a factor cytotoxic for many
malignant cells. It is now clear that it plays an important role in the defense against viral …

Human peripheral Vγ9Vδ2 T cells are activated by phosphorylated metabolites
(phosphoagonists [PAg]) of the mammalian mevalonate or the microbial desoxyxylulose …

Many human melanoma tumors express antigens that are recognized in vitro by cytolytic T
lymphocytes (CTLs) derived from the tumor-bearing patient. A gene was identified that …

Leukocytes respond to lipopolysaccharide (LPS) at nanogram per milliliter concentrations
with secretion of cytokines such as tumor necrosis factor-α (TNF-α). Excess secretion of TNF …

The tetrazolium salt (MTT) method involving conversion of MTT to coloured formazan by
cells serving as indirect measurements of cell growth/cell kill has been reported by several …

Materials and Methods Mice. BALB/c, C57BL/6, and CBA/J mice were obtained from
TheJackson Laboratory (Bar Harbor, ME) and the Institute of Medical Research (SanJose …

BACKGROUND/AIM Proinflammatory cytokines are key factors in the pathogenesis of
Crohn's disease (CD). Activation of nuclear factor kappa B (NFκB), which is involved in their …

Male NMRI or BALB/c mice developed severe liver injury as assessed by transaminase
release within 8 h when an intravenous dose greater than 1.5 mg/kg concanavalin A (Con A) …

The primary structure of lipopolysaccharide binding protein (LBP), a trace plasma protein
that binds to the lipid A moiety of bacterial lipopolysaccharides (LPSs), was deduced by …