Oxidative stress is the consequence of an overproduction of reactive oxygen species (ROS)
that exceeds the antioxidant defense mechanisms. Increased levels of ROS contribute to the …

Statins, which are widely used to treat hypercholesterolemia, have anti-inflammatory and
anti-oxidant effects. These are thought to be responsible for the potential effects of statins on …

Pyroptosis is a novel pro-inflammatory cell programmed death dependent on Gasdermin
(GSMD) family-mediated membrane pore formation and subsequent cell lysis, accompanied …

Cholesterol is an essential component of plasma membrane and precursor of biological
active compounds, including hydroxycholesterols (HCs). HCs regulate cellular homeostasis …

A growing bulk of evidence suggests that cholesterol oxidation products, known as
oxysterols, are potentially involved in the pathogenesis of major chronic diseases, including …

More and more attention is nowadays given to the possible translational application of a
great number of biochemical and biological findings with the involved molecules. This is …

The immune microenvironment in breast cancer (BCa) is controlled by a complex network of
communication between various cell types. Here, we find that recruitment of B lymphocytes …

Significance: Inflammation increases during the aging process. It is linked to mitochondrial
dysfunction and increased reactive oxygen species (ROS) production. Mitochondrial …

Cholesterol oxidation products, also named oxysterols, can be formed either by cholesterol
auto-oxidation, enzymatically or both. Among these oxysterols, 7-ketocholesterol (7KC) is …

Bronchopulmonary dysplasia (BPD) is a chronic lung disease commonly found in premature
infants. Excessive inflammation and oxidative stress contribute to BPD occurrence and …