Carriers break barriers in drug delivery: endocytosis and endosomal escape of gene delivery vectors
IMS Degors, C Wang, ZU Rehman… - Accounts of chemical …, 2019 - ACS Publications
Conspectus Over the past decades, major efforts were undertaken to develop devices on a
nanoscale level for the efficient and nontoxic delivery of molecules to tissues and cells, for …
nanoscale level for the efficient and nontoxic delivery of molecules to tissues and cells, for …
Brief update on endocytosis of nanomedicines
The complexity of nanoscale interactions between biomaterials and cells has limited the
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …
mRNA vaccine delivery using lipid nanoparticles
mRNA vaccines elicit a potent immune response including antibodies and cytotoxic T cells.
mRNA vaccines are currently evaluated in clinical trials for cancer immunotherapy …
mRNA vaccines are currently evaluated in clinical trials for cancer immunotherapy …
Cationic antimicrobial polymers and their assemblies
AM Carmona-Ribeiro… - International journal of …, 2013 - mdpi.com
Cationic compounds are promising candidates for development of antimicrobial agents.
Positive charges attached to surfaces, particles, polymers, peptides or bilayers have been …
Positive charges attached to surfaces, particles, polymers, peptides or bilayers have been …
Multistimuli-responsive supramolecular vesicles based on water-soluble pillar [6] arene and SAINT complexation for controllable drug release
Y Cao, XY Hu, Y Li, X Zou, S ** the endosome: assessing cellular trafficking mechanisms of non-viral vehicles
Non-viral vehicles hold therapeutic promise in advancing the delivery of a variety of cargos
in vitro and in vivo, including small molecule drugs, biologics, and especially nucleic acids …
in vitro and in vivo, including small molecule drugs, biologics, and especially nucleic acids …
Cationic lipids, lipoplexes and intracellular delivery of genes
L Wasungu, D Hoekstra - Journal of Controlled Release, 2006 - Elsevier
As a consequence of several setbacks encountered by viral technology in achieving efficient
and safe gene therapy in clinical trials, non-viral gene delivery vectors are considered to …
and safe gene therapy in clinical trials, non-viral gene delivery vectors are considered to …
Non-viral gene therapy: polycation-mediated DNA delivery
M Thomas, AM Klibanov - Applied microbiology and biotechnology, 2003 - Springer
Gene therapy, ie, the expression in cells of genetic material with therapeutic activity, holds
great promise for the treatment of human diseases. A delivery vehicle (vector), of either viral …
great promise for the treatment of human diseases. A delivery vehicle (vector), of either viral …
Barriers to nonviral gene delivery
CM Wiethoff, CR Middaugh - Journal of pharmaceutical sciences, 2003 - Elsevier
The use of various synthetic lipids and polymers to deliver DNA for gene therapy
applications has been the subject of intense examination for the last 15 years. Our …
applications has been the subject of intense examination for the last 15 years. Our …