Oligodendrocytes are best known for wrap** myelin, a unique specialization that enables
energy-efficient and fast axonal impulse propagation in white matter tracts and fibers of the …

Organismal aging exhibits wide-ranging hallmarks in divergent cell types across tissues,
organs, and systems. The advancement of single-cell technologies and generation of rich …

In mammalian brains, millions to billions of cells form complex interaction networks to enable
a wide range of functions. The enormous diversity and intricate organization of cells have …

Aging is the key risk factor for cognitive decline, yet the molecular changes underlying brain
aging remain poorly understood. Here, we conducted spatiotemporal RNA sequencing of …

Alzheimer's disease (AD) and dementia in general are age-related diseases with multiple
contributing factors, including brain inflammation. Microglia, and specifically those …

Spatial transcriptomics (ST) technologies enable high throughput gene expression
characterization within thin tissue sections. However, comparing spatial observations across …

The prefrontal cortex (PFC) is a complex brain region that regulates diverse functions
ranging from cognition, emotion and executive action to even pain processing. To decode …

Spatial clustering, which shares an analogy with single-cell clustering, has expanded the
scope of tissue physiology studies from cell-centroid to structure-centroid with spatially …

Understanding the complexity of cellular function within a tissue necessitates the
combination of multiple phenotypic readouts. Here, we developed a method that links …

In combination with cell-intrinsic properties, interactions in the tumor microenvironment
modulate therapeutic response. We leveraged single-cell spatial transcriptomics to dissect …