Malaria is a febrile illness caused by species of the protozoan parasite Plasmodium and is
characterized by recursive infections of erythrocytes, leading to clinical symptoms and …

Recent progress in reducing malaria cases and ensuing deaths is threatened by factors like
mutations that induce resistance to artemisinin derivatives. Multiple drugs are currently in …

Malaria eradication is critically dependent on new therapeutics that target resistant
Plasmodium parasites and block transmission of the disease. Here, we report that …

Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria
elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl …

Pantothenamides (PanAms) are potent antiplasmodials with low human toxicity currently
being investigated as antimalarials with a novel mode of action. These structural analogues …

Fungal infections are the leading cause of mortality by eukaryotic pathogens, with an
estimated 150 million severe life-threatening cases and 1.7 million deaths reported …

Introduction The soil-borne vascular fungus Verticillium dahliae is a phytopathogenic fungus
known to attack cotton crop causing Verticillium wilt. In previous study, we identified a …

The emergence of resistance to nearly every therapeutic agent directed against malaria-
causing Plasmodium parasites emphasises the dire need for new antimalarials. Despite …

Coenzyme A is synthesised from pantothenate via five enzyme-mediated steps. The first
step is catalysed by pantothenate kinase (PanK). All PanKs characterised to date form …

Human PANK1, PANK2, and PANK3 genes encode several pantothenate kinase isoforms
that catalyze the phosphorylation of vitamin B5 (pantothenic acid) to phosphopantothenate …