Obsessive‐compulsive disorder: Etiology, neuropathology, and cognitive dysfunction

B Jalal, SR Chamberlain, BJ Sahakian - Brain and behavior, 2023 - Wiley Online Library
Background This review provides an overview of obsessive‐compulsive disorder (OCD)
symptoms, including the four partially distinct subtypes of the disorder, current diagnostic …

Dopaminergic control of cognitive flexibility in humans and animals

M Klanker, M Feenstra, D Denys - Frontiers in neuroscience, 2013 - frontiersin.org
Striatal dopamine (DA) is thought to code for learned associations between cues and
reinforcers and to mediate approach behavior toward a reward. Less is known about the …

Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder

PL Remijnse, MMA Nielen… - Archives of general …, 2006 - jamanetwork.com
Context The orbitofrontal cortex (OFC)–striatal circuit, which is important for motivational
behavior, is assumed to be involved in the pathophysiology of obsessive-compulsive …

The neurobiology of repetitive behavior:… and men

M Langen, S Durston, MJH Kas… - Neuroscience & …, 2011 - Elsevier
In young, typically develo** children, repetitive behavior similar to that in certain
neuropsychiatric syndromes is common. Whereas this behavior is adaptive in typical …

Should an obsessive–compulsive spectrum grou** of disorders be included in DSM‐V?

KA Phillips, DJ Stein, SL Rauch… - Depression and …, 2010 - Wiley Online Library
The obsessive–compulsive (OC) spectrum has been discussed in the literature for two
decades. Proponents of this concept propose that certain disorders characterized by …

Multiple pathways to functional impairment in obsessive–compulsive disorder

Y Markarian, MJ Larson, MA Aldea, SA Baldwin… - Clinical psychology …, 2010 - Elsevier
Obsessive–compulsive disorder (OCD) is a chronic and debilitating condition that is
relatively common in both children and adults, and it is associated with a wide range of …

The prefrontal cortex and OCD

SE Ahmari, SL Rauch - Neuropsychopharmacology, 2022 - nature.com
Abstract Obsessive Compulsive Disorder (OCD) is a highly prevalent and severe
neuropsychiatric disorder, with an incidence of 1.5–3% worldwide. However, despite the …

Response inhibition and interference control in obsessive–compulsive spectrum disorders

LS van Velzen, C Vriend, SJ de Wit… - Frontiers in human …, 2014 - frontiersin.org
Over the past 20 years, motor response inhibition and interference control have received
considerable scientific effort and attention, due to their important role in behavior and the …

Invasive circuitry-based neurotherapeutics: stereotactic ablation and deep brain stimulation for OCD

BD Greenberg, SL Rauch, SN Haber - Neuropsychopharmacology, 2010 - nature.com
Psychiatric neurosurgery, specifically stereotactic ablation, has continued since the 1940s,
mainly at a few centers in Europe and the US. Since the late 1990s, the resurgence of …

Cortical GABA, striatal dopamine and midbrain serotonin as the key players in compulsive and anxiety disorders-results from in vivo imaging studies

S Nikolaus, C Antke, M Beu, HW Müller - Reviews in the …, 2010 - degruyter.com
Various factors are discussed in the pathophysiology of anxiety disorders, including
dysfunctions of the (DA) ergic, serotonin (5-HT) ergic and GABAergic system. We assessed …