Lewy body diseases and the gut
Gastrointestinal (GI) involvement in Lewy body diseases (LBDs) has been observed since
the initial descriptions of patients by James Parkinson. Recent experimental and human …
the initial descriptions of patients by James Parkinson. Recent experimental and human …
A Versatile Method for Site-Specific Chemical Installation of Aromatic Posttranslational Modification Analogs into Proteins
Posttranslational modifications (PTMs) of proteins play central roles in regulating the protein
structure, interactome, and functions. A notable modification site is the aromatic side chain of …
structure, interactome, and functions. A notable modification site is the aromatic side chain of …
The effect of AKT inhibition in α-synuclein-dependent neurodegeneration
B Ranxhi, ZR Bangash, ZM Chbihi, SV Todi… - Frontiers in Molecular …, 2025 - frontiersin.org
Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting millions of
individuals worldwide. A hallmark of PD pathology is the accumulation of α-synuclein (α …
individuals worldwide. A hallmark of PD pathology is the accumulation of α-synuclein (α …
[HTML][HTML] Current safety recommendations for handling mouse and human αsynuclein pre-formed fibrils
Abstract α-Synuclein (α-syn) is a 140-amino acid protein that can form amyloid fibrils. Lewy
bodies and Lewy neurites containing aggregated α-syn are pathological markers of …
bodies and Lewy neurites containing aggregated α-syn are pathological markers of …
Imaging alpha-synuclein pathology in Parkinson's disease
R Ni - Neural Regeneration Research, 2025 - journals.lww.com
Parkinson's disease (PD) is the second most common neurodegenerative disorder. The
clinical manifestations of PD include motor symptoms, such as bradykinesia, resting tremor …
clinical manifestations of PD include motor symptoms, such as bradykinesia, resting tremor …
Formation of Condition-Dependent Alpha-Synuclein Fibril Strain in Artificial Cerebrospinal Fluid
R Snieckute, D Sulskis, A Jocyte, U Venclovaite… - bioRxiv, 2025 - biorxiv.org
α-Synuclein (aSyn) is an intrinsically disordered protein involved in neurotransmission and
synaptic plasticity. The pathological aggregation of this protein is a hallmark of …
synaptic plasticity. The pathological aggregation of this protein is a hallmark of …
[PDF][PDF] Current safety recommendations for handling mouse and human alpha-synuclein fibrils
L Fielding, MA Menard, J Rothb, B Dehayc… - volpicellidaleylab.org
Exposure of neurons to α-synuclein (α-syn) preformed fibrils (PFFs) causes corruption of
endogenously expressed α-syn to form aggregates biochemically and morphologically …
endogenously expressed α-syn to form aggregates biochemically and morphologically …