Activation of mast cells by neuropeptides: the role of pro-inflammatory and anti-inflammatory cytokines

D Lauritano, F Mastrangelo, C D'Ovidio… - International journal of …, 2023 - mdpi.com
Mast cells (MCs) are tissue cells that are derived from bone marrow stem cells that
contribute to allergic reactions, inflammatory diseases, innate and adaptive immunity …

Neurovascular unit, neuroinflammation and neurodegeneration markers in brain disorders

D Kempuraj, KD Dourvetakis, J Cohen… - Frontiers in Cellular …, 2024 - frontiersin.org
Neurovascular unit (NVU) inflammation via activation of glial cells and neuronal damage
plays a critical role in neurodegenerative diseases. Though the exact mechanism of disease …

Microglia depletion ameliorates neuroinflammation, anxiety-like behavior, and cognitive deficits in a sex-specific manner in Rev-erbα knockout mice

R Chen, BN Routh, JE Straetker, CR Gibson… - Brain, Behavior, and …, 2023 - Elsevier
The circadian system is an evolutionarily adaptive system that synchronizes biological and
physiological activities within the body to the 24 h oscillations on Earth. At the molecular …

The potential therapeutic role of itaconate and mesaconate on the detrimental effects of LPS-induced neuroinflammation in the brain

M Ohm, S Hosseini, N Lonnemann, W He… - Journal of …, 2024 - Springer
Despite advances in antimicrobial and anti-inflammatory treatment, inflammation and its
consequences remain a major challenge in the field of medicine. Inflammatory reactions can …

How viral infections cause neuronal dysfunction: a focus on the role of microglia and astrocytes

S Hosseini, M Korte - Biochemical Society Transactions, 2023 - portlandpress.com
In recent decades, a number of infectious viruses have emerged from wildlife or reemerged
that pose a serious threat to global health and economies worldwide. Although many of …

A novel co-culture model for investigation of the effects of LPS-induced macrophage-derived cytokines on brain endothelial cells

J Yang, Y Li, A Bhalla, M Maienschein-Cline, K Fukuchi - Plos one, 2023 - journals.plos.org
In order to study effects of macrophage-derived inflammatory mediators associated with
systemic inflammation on brain endothelial cells, we have established a co-culture system …

Treadmill running and Levisticum Officinale extract protect against LPS-induced memory deficits by modulating neurogenesis, neuroinflammation and oxidative stress

E Amraie, I Pouraboli, H Salehi, Z Rajaei - Metabolic Brain Disease, 2023 - Springer
Neuroinflammation plays an essential role in the pathogenesis of Alzheimer's disease. The
preventive effect of physical exercise on attenuating neuroinflammation has not been …

The role of IL-1 family of cytokines in the pathogenesis and therapy of Alzheimer's disease

CQ Li, X Zhang, Y Wang, L Cheng, CB Li… - Inflammopharmacology, 2024 - Springer
Alzheimer's disease (AD) is a progressive and irreversible neurological condition that occurs
with age and poses a significant global public health concern, is distinguished by the …

Emerging functions and therapeutic targets of IL‐38 in central nervous system diseases

Y Gao, L Cai, Y Wu, M Jiang, Y Zhang… - CNS Neuroscience …, 2024 - Wiley Online Library
Abstract Interleukin (IL)‐38 is a newly discovered cytokine of the IL‐1 family, which binds
various receptors (ie, IL‐36R, IL‐1 receptor accessory protein‐like 1, and IL‐1R1) in the …

Inhibition of Microglial Activation Ameliorates Inflammation, Reduced Neurogenesis in the hippocampus, and Impaired Brain Function in a Rat Model of Bilirubin …

Y Zhang, S Li, L Li, H Huang, Z Fu, Z Hua - Journal of Neuroimmune …, 2024 - Springer
Hyperbilirubinemia is one of the most common occurrence in newborns and is toxic to the
brain, resulting in neurological sequelae such as auditory impairment, with potential to …