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Activation of mast cells by neuropeptides: the role of pro-inflammatory and anti-inflammatory cytokines
Mast cells (MCs) are tissue cells that are derived from bone marrow stem cells that
contribute to allergic reactions, inflammatory diseases, innate and adaptive immunity …
contribute to allergic reactions, inflammatory diseases, innate and adaptive immunity …
Neurovascular unit, neuroinflammation and neurodegeneration markers in brain disorders
D Kempuraj, KD Dourvetakis, J Cohen… - Frontiers in Cellular …, 2024 - frontiersin.org
Neurovascular unit (NVU) inflammation via activation of glial cells and neuronal damage
plays a critical role in neurodegenerative diseases. Though the exact mechanism of disease …
plays a critical role in neurodegenerative diseases. Though the exact mechanism of disease …
Microglia depletion ameliorates neuroinflammation, anxiety-like behavior, and cognitive deficits in a sex-specific manner in Rev-erbα knockout mice
The circadian system is an evolutionarily adaptive system that synchronizes biological and
physiological activities within the body to the 24 h oscillations on Earth. At the molecular …
physiological activities within the body to the 24 h oscillations on Earth. At the molecular …
The potential therapeutic role of itaconate and mesaconate on the detrimental effects of LPS-induced neuroinflammation in the brain
M Ohm, S Hosseini, N Lonnemann, W He… - Journal of …, 2024 - Springer
Despite advances in antimicrobial and anti-inflammatory treatment, inflammation and its
consequences remain a major challenge in the field of medicine. Inflammatory reactions can …
consequences remain a major challenge in the field of medicine. Inflammatory reactions can …
How viral infections cause neuronal dysfunction: a focus on the role of microglia and astrocytes
S Hosseini, M Korte - Biochemical Society Transactions, 2023 - portlandpress.com
In recent decades, a number of infectious viruses have emerged from wildlife or reemerged
that pose a serious threat to global health and economies worldwide. Although many of …
that pose a serious threat to global health and economies worldwide. Although many of …
A novel co-culture model for investigation of the effects of LPS-induced macrophage-derived cytokines on brain endothelial cells
J Yang, Y Li, A Bhalla, M Maienschein-Cline, K Fukuchi - Plos one, 2023 - journals.plos.org
In order to study effects of macrophage-derived inflammatory mediators associated with
systemic inflammation on brain endothelial cells, we have established a co-culture system …
systemic inflammation on brain endothelial cells, we have established a co-culture system …
Treadmill running and Levisticum Officinale extract protect against LPS-induced memory deficits by modulating neurogenesis, neuroinflammation and oxidative stress
Neuroinflammation plays an essential role in the pathogenesis of Alzheimer's disease. The
preventive effect of physical exercise on attenuating neuroinflammation has not been …
preventive effect of physical exercise on attenuating neuroinflammation has not been …
The role of IL-1 family of cytokines in the pathogenesis and therapy of Alzheimer's disease
CQ Li, X Zhang, Y Wang, L Cheng, CB Li… - Inflammopharmacology, 2024 - Springer
Alzheimer's disease (AD) is a progressive and irreversible neurological condition that occurs
with age and poses a significant global public health concern, is distinguished by the …
with age and poses a significant global public health concern, is distinguished by the …
Emerging functions and therapeutic targets of IL‐38 in central nervous system diseases
Y Gao, L Cai, Y Wu, M Jiang, Y Zhang… - CNS Neuroscience …, 2024 - Wiley Online Library
Abstract Interleukin (IL)‐38 is a newly discovered cytokine of the IL‐1 family, which binds
various receptors (ie, IL‐36R, IL‐1 receptor accessory protein‐like 1, and IL‐1R1) in the …
various receptors (ie, IL‐36R, IL‐1 receptor accessory protein‐like 1, and IL‐1R1) in the …
Inhibition of Microglial Activation Ameliorates Inflammation, Reduced Neurogenesis in the hippocampus, and Impaired Brain Function in a Rat Model of Bilirubin …
Y Zhang, S Li, L Li, H Huang, Z Fu, Z Hua - Journal of Neuroimmune …, 2024 - Springer
Hyperbilirubinemia is one of the most common occurrence in newborns and is toxic to the
brain, resulting in neurological sequelae such as auditory impairment, with potential to …
brain, resulting in neurological sequelae such as auditory impairment, with potential to …