Drug metabolism and pharmacokinetics (DMPK) is an important branch of pharmaceutical
sciences. The nature of ADME (absorption, distribution, metabolism, excretion) and PK …

The liver represents a major eliminating and detoxifying organ, determining exposure to
endogenous compounds, drugs, and other xenobiotics. Drug transporters (DTs) and drug …

Liver cirrhosis is a chronic disease that affects the liver structure, protein expression, and
overall metabolic function. Abundance data for drug-metabolizing enzymes and transporters …

The availability of assays that predict the contribution of cytochrome P450 (CYP) metabolism
allows for the design of new chemical entities (NCEs) with minimal oxidative metabolism …

Protein abundance data of drug-metabolizing enzymes and transporters (DMETs) are useful
for scaling in vitro and animal data to humans for accurate prediction and interpretation of …

A reliable translation of in vitro and preclinical data on drug absorption, distribution,
metabolism, and excretion (ADME) to humans is important for safe and effective drug …

Pharmacogenomic (PGx) testing of cytochrome P450 (CYP) enzymes may improve the
efficacy and/or safety of some medications. This is facilitated by increased availability and …

For many years, the medical community has relied in clinical practice on historic data about
the physiological changes that occur during pregnancy. However, some newer studies have …

Cannabidiol (CBD) is available as a prescription oral drug that is indicated for the treatment
of some types of epilepsy in children and adults. CBD is also available over-the-counter and …

Pregnancy can significantly change the pharmacokinetics of drugs, including those renally
secreted by organic anion transporters (OATs). Quantifying these changes in pregnant …