The human genome is thought to harbor 50,000 to 100,000 genes, of which about half have
been sampled to date in the form of expressed sequence tags. An international consortium …

Levels of heterozygosity for single nucleotide polymorphisms vary by more than one order of
magnitude in different regions of the human genome. Regional differences in the rate of …

The hypothalamus plays a central role in the integrated control of feeding and energy
homeostasis. We have identified two novel neuropeptides, both derived from the same …

Human sex chromosomes evolved from autosomes. Nineteen ancestral autosomal genes
persist as differentiated homologs on the X and Y chromosomes. The ages of individual XY …

Chromosome 21 is the smallest human autosome. An extra copy of chromosome 21 causes
Down syndrome, the most frequent genetic cause of significant mental retardation, which …

Gene amplifications and deletions frequently contribute to tumorigenesis. Characterization
of these DNA copy-number changes is important for both the basic understanding of cancer …

DGAT1 encodes diacylglycerol O-acyltransferase (EC 2.3. 1.20), a microsomal enzyme that
catalyzes the final step of triglyceride synthesis. It became a functional candidate gene for …

Partial overlap** cDNA sequences likely to encode a novel human CC chemokine were
identified from the GenBank Expressed Sequence Tag data base. Using these sequences …

The highly specific and sensitive PCR provides the basis for sequence-tagged sites (STSs),
unique landmarks that have been used widely in the construction of genetic and physical …

We report here the cloning and characterization of four new members of the interleukin-1 (IL-
1) family (FIL1δ, FIL1ε, FIL1ζ, and FIL1η, with FIL1 standing for" Family of IL-1"). The novel …