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Genome folding through loop extrusion by SMC complexes
IF Davidson, JM Peters - Nature reviews Molecular cell biology, 2021 - nature.com
Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …
serve important structural and regulatory roles. It has been proposed that these genomic …
Loo** the genome with SMC complexes
SMC (structural maintenance of chromosomes) protein complexes are an evolutionarily
conserved family of motor proteins that hold sister chromatids together and fold genomes …
conserved family of motor proteins that hold sister chromatids together and fold genomes …
All eukaryotic SMC proteins induce a twist of− 0.6 at each DNA loop extrusion step
Eukaryotes carry three types of structural maintenance of chromosome (SMC) protein
complexes, condensin, cohesin, and SMC5/6, which are ATP-dependent motor proteins that …
complexes, condensin, cohesin, and SMC5/6, which are ATP-dependent motor proteins that …
Cohesin mediates DNA loop extrusion by a “swing and clamp” mechanism
BW Bauer, IF Davidson, D Canena, G Wutz, W Tang… - Cell, 2021 - cell.com
Structural maintenance of chromosomes (SMC) complexes organize genome topology in all
kingdoms of life and have been proposed to perform this function by DNA loop extrusion …
kingdoms of life and have been proposed to perform this function by DNA loop extrusion …
[HTML][HTML] SMC complexes can traverse physical roadblocks bigger than their ring size
Ring-shaped structural maintenance of chromosomes (SMC) complexes like condensin and
cohesin extrude loops of DNA. It remains, however, unclear how they can extrude DNA …
cohesin extrude loops of DNA. It remains, however, unclear how they can extrude DNA …
A hold-and-feed mechanism drives directional DNA loop extrusion by condensin
IA Shaltiel, S Datta, L Lecomte, M Hassler… - Science, 2022 - science.org
Structural maintenance of chromosomes (SMC) protein complexes structure genomes by
extruding DNA loops, but the molecular mechanism that underlies their activity has …
extruding DNA loops, but the molecular mechanism that underlies their activity has …
[HTML][HTML] CTCF and R-loops are boundaries of cohesin-mediated DNA loo**
Cohesin and CCCTC-binding factor (CTCF) are key regulatory proteins of three-dimensional
(3D) genome organization. Cohesin extrudes DNA loops that are anchored by CTCF in a …
(3D) genome organization. Cohesin extrudes DNA loops that are anchored by CTCF in a …
An extrinsic motor directs chromatin loop formation by cohesin
TM Guérin, C Barrington, G Pobegalov… - The EMBO …, 2024 - embopress.org
The ring-shaped cohesin complex topologically entraps two DNA molecules to establish
sister chromatid cohesion. Cohesin also shapes the interphase chromatin landscape with …
sister chromatid cohesion. Cohesin also shapes the interphase chromatin landscape with …
NIPBL and cohesin: new take on a classic tale
D Alonso-Gil, A Losada - Trends in cell biology, 2023 - cell.com
Cohesin folds the genome in dynamic chromatin loops and holds the sister chromatids
together. NIPBL Scc2 is currently considered the cohesin loader, a role that may need …
together. NIPBL Scc2 is currently considered the cohesin loader, a role that may need …
Mechanisms of chromosome folding and nuclear organization: their interplay and open questions
Microscopy and genomic approaches provide detailed descriptions of the three-dimensional
folding of chromosomes and nuclear organization. The fundamental question is how activity …
folding of chromosomes and nuclear organization. The fundamental question is how activity …