The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and
finding a safe therapeutic strategy and effective vaccine is critical to overcoming severe …

Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with a high
individual and societal burden. While not all patients display overt markers of elevated …

Scientists and health professionals are exhaustively trying to contain the coronavirus
disease 2019 (COVID-19) pandemic by elucidating viral invasion mechanisms, possible …

Microglia, brain resident immune cells, modulate development, activity, and plasticity of the
central nervous system. Mechanistically implicated in numerous neurological pathologies …

Background The purinergic ATP-gated P2X7 receptor (P2X7R) is increasingly recognized to
contribute to pathological neuroinflammation and brain hyperexcitability. P2X7R expression …

The effects of celecoxib on a broad spectrum of mood disorders and on inflammatory
parameters have not yet been comprehensively evaluated. The aim of this study was to …

Background Pain is generally concomitant with an inflammatory reaction at the site where
the nociceptive fibers are activated. Rodent studies suggest that a sterile meningeal …

Glioblastoma (GBM) is the most lethal brain tumor in adults. Radiation, together with
temozolomide is the standard treatment, but nevertheless, relapse occurs in nearly all cases …

P2X7 receptors are ion-gated channels activated by ATP. Under pathological conditions, the
extensive release of ATP induces sustained P2X7 receptor activation, culminating in …

The P2X7 receptor, originally known as the P2Z receptor due to its distinctive functional
properties, has a structure characteristic of the ATP-gated ion channel P2X receptor family …