Flavonoids as anticancer agents

DM Kopustinskiene, V Jakstas, A Savickas… - Nutrients, 2020 - mdpi.com
Flavonoids are polyphenolic compounds subdivided into 6 groups: isoflavonoids,
flavanones, flavanols, flavonols, flavones and anthocyanidins found in a variety of plants …

Naringin and naringenin: Their mechanisms of action and the potential anticancer activities

J Stabrauskiene, DM Kopustinskiene, R Lazauskas… - Biomedicines, 2022 - mdpi.com
Naringin and naringenin are the main bioactive polyphenols in citrus fruits, the consumption
of which is beneficial for human health and has been practiced since ancient times …

The role of mitochondria in inflammation: from cancer to neurodegenerative disorders

S Missiroli, I Genovese, M Perrone, B Vezzani… - Journal of clinical …, 2020 - mdpi.com
The main features that are commonly attributed to mitochondria consist of the regulation of
cell proliferation, ATP generation, cell death and metabolism. However, recent scientific …

Polyphenols in cancer prevention: New insights

G Briguglio, C Costa, M Pollicino… - International …, 2020 - spandidos-publications.com
A huge volume of literature data suggests that a diet rich in fruits and vegetables, mostly due
to the contribution of natural polyphenols, could reduce the incidence of specific cancers …

The mitochondrial unfolded protein response (UPRmt): shielding against toxicity to mitochondria in cancer

JR Inigo, D Chandra - Journal of hematology & oncology, 2022 - Springer
Mitochondria are essential for tumor growth and progression. However, the heavy demand
for mitochondrial activity in cancer leads to increased production of mitochondrial reactive …

MALDI-IHC-guided in-depth spatial proteomics: targeted and untargeted MSI combined

BSR Claes, KK Krestensen, G Yagnik, A Grgic… - Analytical …, 2023 - ACS Publications
Recently, a novel technology was published, utilizing the strengths of matrix-assisted laser
desorption/ionization (MALDI) mass spectrometry imaging (MSI) and immunohistochemistry …

Phenolic Compounds of Rhodiola rosea L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases

J Bernatoniene, V Jakstas… - International journal of …, 2023 - mdpi.com
The roots and rhizomes of Rhodiola rosea L.(Crassulaceae), which is widely growing in
Northern Europe, North America, and Siberia, have been used since ancient times to …

Role of stress in the pathogenesis of cancer

IG Lempesis, VE Georgakopoulou… - International …, 2023 - spandidos-publications.com
Stress is a state of disrupted homeostasis, triggered by intrinsic or extrinsic factors, the
stressors, which are counteracted by various physiological and behavioural adaptive …

Role of mitochondrial alterations in human cancer progression and cancer immunity

SF Wang, LM Tseng, HC Lee - Journal of biomedical science, 2023 - Springer
Dysregulating cellular metabolism is one of the emerging cancer hallmarks. Mitochondria
are essential organelles responsible for numerous physiologic processes, such as energy …

Hyaluronan and reactive oxygen species signaling—novel cues from the matrix?

A Berdiaki, M Neagu, I Spyridaki, A Kuskov, S Perez… - Antioxidants, 2023 - mdpi.com
Hyaluronan (HA) is a naturally occurring non-sulfated glycosaminoglycan (GAG) localized to
the cell surface and the tissue extracellular matrix (ECM). It is composed of disaccharides …