The development of combination immunotherapy based on the mediation of regulatory
mechanisms of the tumor immune microenvironment (TIME) is promising. However, a deep …

The cellular oxidation and reduction (redox) environment is influenced by the production
and removal of reactive oxygen species (ROS). In recent years, several reports support the …

Purpose: To identify a clinically relevant and available parameter upon which to identify non-
small cell lung cancer (NSCLC) patients at risk for pneumonitis when treated with three …

Radiation therapy is one of the most common treatment strategies for thorax malignancies.
One of the considerable limitations of this therapy is its toxicity to normal tissue. The lung is …

Radiation therapy (RT) for thoracic-region tumors often causes lung injury. The incidence of
lung toxicity depends on the method of assessment (eg, radiographs, patient's symptoms, or …

Purpose: To investigate prospectively the utility of plasma transforming growth factor β1
(TGFβ1) as a marker for the development of symptomatic radiation pneumonitis. Materials …

Radiation-induced alterations in cellular tissue homeostasis triggered by various molecular
responses at the level of inter-and intracellular signaling processes cause both acute and …

Any tumor could be controlled by radiation therapy if sufficient dose were delivered to all
tumor cells. Although technological advances in physical treatment delivery have been …

The decision to administer a radical course of radiotherapy (RT) is largely influenced by the
dose-volume metrics of the treatment plan, but what are the patient-related and other factors …

Normal tissue injury from irradiation is an unfortunate consequence of radiotherapy.
Technologic improvements have reduced the risk of normal tissue injury; however, toxicity …