The DNA damage response (DDR) is an organized network of multiple interwoven
components evolved to repair damaged DNA and maintain genome fidelity. Conceptually …

The deoxyribonucleic acid (DNA) damage response (DDR) is a major feature in the
maintenance of genome integrity and in the suppression of tumorigenesis. PALB2 (Partner …

The cell cycle is canonically described as a series of four consecutive phases: G1, S, G2,
and M. In single cells, the duration of each phase varies, but the quantitative laws that …

Cells have evolved a robust and highly regulated DNA damage response to preserve their
genomic integrity. Although increasing evidence highlights the relevance of RNA regulation …

Numerous proteins are involved in the multiple pathways of the DNA damage response
network and play a key role to protect the genome from the wide variety of damages that can …

Protein kinases are essential for signal transduction and control of most cellular processes,
including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of …

Evolutionary annotation of genome maintenance (GM) proteins has conventionally been
established by remote relationships within protein sequence databases. However, often no …

Background The maintenance of genomic integrity is the responsibility of a complex
network, denominated the DNA damage response (DDR), which controls the lesion …

Genotoxic stress activates the DNA‐damage response (DDR) signalling cascades
responsible for maintaining genome integrity. Downstream DNA repair pathways include the …

Cancer is a complex disease in which unrestrained cell proliferation results in tumour
development. Extensive research into the molecular mechanisms underlying tumorigenesis …