Olfactory sensing and navigation in turbulent environments

G Reddy, VN Murthy… - Annual Review of …, 2022 - annualreviews.org
Fluid turbulence is a double-edged sword for the navigation of macroscopic animals, such
as birds, insects, and rodents. On the one hand, turbulence enables pheromone …

Principles of odor coding in vertebrates and artificial chemosensory systems

I Manzini, D Schild, C Di Natale - Physiological reviews, 2022 - journals.physiology.org
The biological olfactory system is the sensory system responsible for the detection of the
chemical composition of the environment. Several attempts to mimic biological olfactory …

Widespread receptor-driven modulation in peripheral olfactory coding

L Xu, W Li, V Voleti, DJ Zou, EMC Hillman, S Firestein - Science, 2020 - science.org
INTRODUCTION The mammalian nose is arguably the best chemical sensor on the planet,
able to detect and discriminate among a large and diverse repertoire of mostly small …

Odor coding in the mammalian olfactory epithelium

SM Kurian, RG Naressi, D Manoel, AS Barwich… - Cell and Tissue …, 2021 - Springer
Noses are extremely sophisticated chemical detectors allowing animals to use scents to
interpret and navigate their environments. Odor detection starts with the activation of odorant …

Odorant receptor inhibition is fundamental to odor encoding

P Pfister, BC Smith, BJ Evans, JH Brann, C Trimmer… - Current Biology, 2020 - cell.com
Most natural odors are complex mixtures of volatile components, competing to bind odorant
receptors (ORs) expressed in olfactory sensory neurons (OSNs) of the nose. To date …

Antagonistic odor interactions in olfactory sensory neurons are widespread in freely breathing mice

JD Zak, G Reddy, M Vergassola, VN Murthy - Nature communications, 2020 - nature.com
Odor landscapes contain complex blends of molecules that each activate unique,
overlap** populations of olfactory sensory neurons (OSNs). Despite the presence of …

Widespread inhibition, antagonism, and synergy in mouse olfactory sensory neurons in vivo

S Inagaki, R Iwata, M Iwamoto, T Imai - Cell reports, 2020 - cell.com
Sensory information is selectively or non-selectively enhanced and inhibited in the brain, but
it remains unclear whether and how this occurs at the most peripheral level. Using in vivo …

Competitive binding predicts nonlinear responses of olfactory receptors to complex mixtures

V Singh, NR Murphy… - Proceedings of the …, 2019 - National Acad Sciences
In color vision, the quantitative rules for mixing lights to make a target color are well
understood. By contrast, the rules for mixing odorants to make a target odor remain elusive …

Distinct information conveyed to the olfactory bulb by feedforward input from the nose and feedback from the cortex

JD Zak, G Reddy, V Konanur, VN Murthy - Nature Communications, 2024 - nature.com
Sensory systems are organized hierarchically, but feedback projections frequently disrupt
this order. In the olfactory bulb (OB), cortical feedback projections numerically match sensory …

Allosteric modulation of a human odorant receptor

C Trimmer, R Arroyave, C Vuilleumier, L Wu, A Dumer… - Current Biology, 2023 - cell.com
Odor perception is first determined by how the myriad of environmental volatiles are
detected at the periphery of the olfactory system. The combinatorial activation of dedicated …