Phytochemical Characterization, Functional Nutrition, and Anti-Diabetic Potentials of Leptadenia hastata (pers) Decne Leaves: In Silico and In Vitro Studies

IF Chukwuma, FN Nworah, VO Apeh… - … and Biology Insights, 2022 - journals.sagepub.com
The geometrical increase in diabetes mellitus (DM) and the undesirable side effects of
synthetic drugs have intensified efforts to search for an effective and safe anti-diabetic …

New quinoxaline compounds as DPP-4 inhibitors and hypoglycemics: design, synthesis, computational and bio-distribution studies

YM Syam, MM Anwar, SS Abd El-Karim, SA Elseginy… - RSC …, 2021 - pubs.rsc.org
The current work represents the design and synthetic approaches of a new set of
compounds 6–10 bearing the 1, 4-dimethyl-2, 3-dioxo-1, 2, 3, 4-tetrahydroquinoxaline-6 …

Structure-based virtual screening, molecular docking, molecular dynamics simulation and MM/PBSA calculations towards identification of steroidal and non-steroidal …

F Zare, A Solhjoo, H Sadeghpour… - Journal of …, 2023 - Taylor & Francis
Glucocorticoids have been used in the treatment of many diseases including inflammatory
and autoimmune diseases. Despite the wide therapeutic effects of synthetic glucocorticoids …

Investigation of candidate genes and mechanisms underlying obesity associated type 2 diabetes mellitus using bioinformatics analysis and screening of small drug …

G Prashanth, B Vastrad, A Tengli, C Vastrad… - BMC Endocrine …, 2021 - Springer
Background Obesity associated type 2 diabetes mellitus is a metabolic disorder; however,
the etiology of obesity associated type 2 diabetes mellitus remains largely unknown. There …

[PDF][PDF] A search for novel antidiabetic agents using ligand-based drug design and molecular docking studies employing human intestinal maltase-glucoamylase as …

KS Aminu, A Uzairu, ABU Shallangwa - Adv J Chem A, 2023 - sid.ir
Insulin secretion and action deficiencies can cause elevated blood sugar levels, resulting in
a serious metabolic disorder known as “Diabetes mellitus”. The disease is categorized into …

Synthesis, in silico studies and biological screening of (E)-2-(3-(substitutedstyryl)-5-(substitutedphenyl)-4,5-dihydropyrazol-1-yl)benzo[d]thiazole derivatives as an …

M Kumar, V Kumar, V Singh, S Thakral - BMC chemistry, 2022 - Springer
A new series of (E)-2-(3-(substitutedstyryl)-5-(substitutedphenyl)-4, 5-dihydropyrazol-1-yl)
benzo [d] thiazole derivatives was synthesized and the chemical structures of synthesized …

Synthesis, crystal structural determination and in silco biological studies of 3, 3′-ethane-1, 2-diylbis (2-benzylidene-1, 3-thiazolidin-4-one

LH Abdel-Rahman, SK Mohamed, Y El Bakri… - Journal of Molecular …, 2021 - Elsevier
Abstract A new thiazolidine derivative, 3, 3′-ethane-1, 2-diylbis (2-benzylidene-1, 3-
thiazolidin-4-one (4) was synthesized and the product obtained was characterized by NMR …

The antihyperglycemic potential of pyrazolobenzothiazine 1, 1-dioxide novel derivative in mice using integrated molecular pharmacological approach

S Taj, UA Ashfaq, M Ahmad, H Noor, A Ikram… - Scientific Reports, 2024 - nature.com
Diabetes Mellitus is a metabolic disease characterized by elevated blood sugar levels
caused by inadequate insulin production, which subsequently leads to hyperglycemia. This …

Review Artikel: Docking Molekuler Obat Anti Diabetes Melitus

I Elsiana, K Ulum, KA Kurnia… - Journal of …, 2023 - journal-jps.com
Diabetes mellitus is a disease caused by damage to the pancreas organ such as insulin
secretion abnormalities, insulin resistance, and insufficient production of the hormone …

In silico study of inhibition activity of boceprevir drug against 2019-nCoV main protease

G Tiwari, MS Chauhan, D Sharma - Zeitschrift für Naturforschung C, 2024 - degruyter.com
Boceprevir drug is a ketoamide serine protease inhibitor with a linear peptidomimetic
structure that exhibits inhibition activity against 2019-nCoV main protease. This paper …