Structural and molecular mechanisms for the control of eukaryotic 5′–3′ mRNA decay
3′ RNA decay pathways are critical for quality control and regulation of gene expression.
Structural and biochemical studies have provided insights into the key nucleases that carry …
Structural and biochemical studies have provided insights into the key nucleases that carry …
The role of disordered protein regions in the assembly of decap** complexes and RNP granules
The removal of the 5′ cap structure by the decap** enzyme DCP2 inhibits translation
and generally commits the mRNA to irreversible 5′-to-3′ exonucleolytic degradation by …
and generally commits the mRNA to irreversible 5′-to-3′ exonucleolytic degradation by …
The translation inhibitor rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA
S Iwasaki, W Iwasaki, M Takahashi, A Sakamoto… - Molecular cell, 2019 - cell.com
A class of translation inhibitors, exemplified by the natural product rocaglamide A (RocA),
isolated from Aglaia genus plants, exhibits antitumor activity by clam** eukaryotic …
isolated from Aglaia genus plants, exhibits antitumor activity by clam** eukaryotic …
Biomolecular condensates amplify mRNA decap** by biasing enzyme conformation
Cells organize biochemical processes into biological condensates. P-bodies are
cytoplasmic condensates that are enriched in enzymes important for mRNA degradation and …
cytoplasmic condensates that are enriched in enzymes important for mRNA degradation and …
A direct interaction between DCP1 and XRN1 couples mRNA decap** to 5′ exonucleolytic degradation
The removal of the mRNA 5′ cap structure by the decap** enzyme DCP2 leads to rapid
5′→ 3′ mRNA degradation by XRN1, suggesting that the two processes are coordinated …
5′→ 3′ mRNA degradation by XRN1, suggesting that the two processes are coordinated …
The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals
LC Watson, KM Kuchenbecker, BJ Schiller… - Nature structural & …, 2013 - nature.com
Glucocorticoid receptor (GR) binds to genomic response elements and regulates gene
transcription with cell and gene specificity. Within a response element, the precise sequence …
transcription with cell and gene specificity. Within a response element, the precise sequence …
The activation of the decap** enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1
The removal of the 5′-cap structure by the decap** enzyme DCP2 and its coactivator
DCP1 shuts down translation and exposes the mRNA to 5′-to-3′ exonucleolytic …
DCP1 shuts down translation and exposes the mRNA to 5′-to-3′ exonucleolytic …
Structural and functional control of the eukaryotic mRNA decap** machinery
M Arribas-Layton, D Wu, J Lykke-Andersen… - Biochimica et Biophysica …, 2013 - Elsevier
The regulation of mRNA degradation is critical for proper gene expression. Many major
pathways for mRNA decay involve the removal of the 5′ 7-methyl guanosine (m7G) cap in …
pathways for mRNA decay involve the removal of the 5′ 7-methyl guanosine (m7G) cap in …
Eukaryotic mRNA decap** activation
E Vidya, TF Duchaine - Frontiers in Genetics, 2022 - frontiersin.org
The 5′-terminal cap is a fundamental determinant of eukaryotic gene expression which
facilitates cap-dependent translation and protects mRNAs from exonucleolytic degradation …
facilitates cap-dependent translation and protects mRNAs from exonucleolytic degradation …
Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity
The glucocorticoid receptor (GR) binds as a homodimer to genomic response elements,
which have particular sequence and shape characteristics. Here we show that the …
which have particular sequence and shape characteristics. Here we show that the …