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Co-inhibition of HDAC and MLL-menin interaction targets MLL-rearranged acute myeloid leukemia cells via disruption of DNA damage checkpoint and DNA repair
J Ye, J Zha, Y Shi, Y Li, D Yuan, Q Chen, F Lin… - Clinical …, 2019 - Springer
While the aberrant translocation of the mixed-lineage leukemia (MLL) gene drives
pathogenesis of acute myeloid leukemia (AML), it represents an independent predictor for …
pathogenesis of acute myeloid leukemia (AML), it represents an independent predictor for …
Acute myeloid leukemia with t(8;16)(p11.2;p13.3)/KAT6A-CREBBP in adults
Abstract t (8; 16)(p11. 2; p13. 3)/KAT6A-CREBBP is a rare recurrent cytogenetic abnormality
associated with acute myeloid leukemia (AML). We report 15 cases with t (8; 16)(p11. 2; p13 …
associated with acute myeloid leukemia (AML). We report 15 cases with t (8; 16)(p11. 2; p13 …
High expression of an intragenic long noncoding RNA misinterpreted as high FTO oncogene expression in NPM1 mutant acute myeloid leukemia
S Arza-Apalategi, BMH Heuts, MTM Dooijes, D Gilissen… - Leukemia, 2023 - nature.com
FTO (fat mass and obesity-associated protein) is an N6-methyladenosine RNA demethylase
that plays a role in acute myeloid leukemia (AML) development through onco-transcript …
that plays a role in acute myeloid leukemia (AML) development through onco-transcript …
The neuronal homeobox transcription factor HMX3 is a crucial vulnerability factor in MECOM-negative KMT2A:: MLLT3 acute myelomonocytic leukemia
S Arza-Apalategi, BMH Heuts, SM Bergevoet… - bioRxiv, 2023 - biorxiv.org
Abstract The KMT2A:: MLLT3 fusion protein causes acute myeloid leukemia (AML) by
activating the oncogenic transcription factor MECOM. However, MECOM expression occurs …
activating the oncogenic transcription factor MECOM. However, MECOM expression occurs …
Integrated transcriptomic and epigenetic data analysis identifiesaberrant expression of genes in acute myeloid leukemia with MLL-AF9 translocation
F Wang, Z Li, G Wang, X Tian… - Molecular …, 2020 - spandidos-publications.com
Rearrangement of the mixed lineage leukemia (MLL; also known as lysine
methyltransferase 2A) gene is a recurrent genomic aberration in acute myeloid leukemia …
methyltransferase 2A) gene is a recurrent genomic aberration in acute myeloid leukemia …
[PDF][PDF] Erfelijke trombocytopenie en myeloïde leukemie door verstoorde genregulatie
AE Marneth - ariez.nl
Het proefschrift van dr. Anna Marneth behandelt erfelijke bloedingsneigingen en
bloedplaatjesafwijkingen veroorzaakt door mutaties in de transcriptiefactoren GFI1B (Growth …
bloedplaatjesafwijkingen veroorzaakt door mutaties in de transcriptiefactoren GFI1B (Growth …
C-terminal BRE inhibits cellular proliferation and increases sensitivity to chemotherapeutic drugs of MLL-AF9 acute myeloid leukemia cells
CCM Pun, KKH Lee, YL Chui - Leukemia & Lymphoma, 2019 - Taylor & Francis
Abstract BRE (Brain and Reproductive Organ-Expressed) is an anti-apoptotic protein and a
core component of DNA-repair BRCA1-A complex. Microarray-detected high BRE gene …
core component of DNA-repair BRCA1-A complex. Microarray-detected high BRE gene …