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Viruses, microRNAs, and host interactions
One of the most significant recent advances in biomedical research has been the discovery
of the∼ 22-nt-long class of noncoding RNAs designated microRNAs (miRNAs). These …
of the∼ 22-nt-long class of noncoding RNAs designated microRNAs (miRNAs). These …
Viral and cellular microRNAs as determinants of viral pathogenesis and immunity
MicroRNAs (miRNAs) have recently emerged as key posttranscriptional regulators of gene
expression in multicellular eukaryotes. It is increasingly clear that miRNAs of both viral and …
expression in multicellular eukaryotes. It is increasingly clear that miRNAs of both viral and …
The role of RNAi and microRNAs in animal virus replication and antiviral immunity
The closely related microRNA (miRNA) and RNAi pathways have emerged as important
regulators of virus–host cell interactions. Although both pathways are relatively well …
regulators of virus–host cell interactions. Although both pathways are relatively well …
A human cytomegalovirus-encoded microRNA regulates expression of multiple viral genes involved in replication
Although multiple studies have documented the expression of over 70 novel virus-encoded
microRNAs (miRNAs), the targets and functions of most of these regulatory RNA species are …
microRNAs (miRNAs), the targets and functions of most of these regulatory RNA species are …
Viral and cellular messenger RNA targets of viral microRNAs
Given the propensity of viruses to co-opt cellular pathways and activities for their benefit, it is
perhaps not surprising that several viruses have now been shown to reshape the cellular …
perhaps not surprising that several viruses have now been shown to reshape the cellular …
Marek's disease vaccines: a solution for today but a worry for tomorrow?
Marek's disease (MD) is a lymphoproliferative disease of chickens that, in the absence of
control measures, is capable of causing devastating losses in commercial poultry flocks. MD …
control measures, is capable of causing devastating losses in commercial poultry flocks. MD …
Hepatitis B virus-encoded microRNA controls viral replication
MicroRNAs (miRNAs) are a class of small, single-stranded, noncoding, functional RNAs.
Hepatitis B virus (HBV) is an enveloped DNA virus with virions and subviral forms of …
Hepatitis B virus (HBV) is an enveloped DNA virus with virions and subviral forms of …
Cellular versus viral microRNAs in host–virus interaction
MicroRNAs (miRNAs) mark a new paradigm of RNA-directed gene expression regulation in
a wide spectrum of biological systems. These small non-coding RNAs can contribute to the …
a wide spectrum of biological systems. These small non-coding RNAs can contribute to the …
Human cytomegalovirus infection alters the expression of cellular microRNA species that affect its replication
The human genome encodes over 500 microRNAs (miRNAs), small RNAs (19 to 26
nucleotides [nt]) that regulate the expressions of diverse cellular genes. Many cellular …
nucleotides [nt]) that regulate the expressions of diverse cellular genes. Many cellular …
A functional MicroRNA-155 ortholog encoded by the oncogenic Marek's disease virus
Kaposi's sarcoma-associated herpesvirus-encoded microRNA (miRNA) MiR-K12-11 was
recently shown to be a functional ortholog of miR-155, a miRNA that plays a major role in …
recently shown to be a functional ortholog of miR-155, a miRNA that plays a major role in …