Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that
neutrophils play an important role in the pathophysiology, particularly in those with severe …

Abstract Coronavirus disease 2019 (Covid-19) is a worldwide infectious disease caused by
severe acute respiratory coronavirus 2 (SARS-CoV-2). In severe SARS-CoV-2 infection …

Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to
cytokine storm syndrome, organ dysfunction, and death. Considering that neutrophil …

Background: The recent outbreak of coronavirus disease 2019 (COVID-19) has been rapidly
spreading on a global scale and poses a great threat to human health. Acute respiratory …

Unusually for a viral infection, the immunological phenotype of severe COVID-19 is
characterised by a depleted lymphocyte and elevated neutrophil count, with the neutrophil …

Neutrophil extracellular traps (NETs), a web-like structures containing chromatin, have a
significant role in assisting the capture and killing of microorganisms by neutrophils during …

Beyond their well-known functions in the acute phases of the immune response, neutrophils
play important roles in the various phases of tumor initiation and progression, through the …

Evidence shows that neutrophils can protect the host against pathogens in multiple ways,
including the formation and release of neutrophil extracellular traps (NETs). NETs are web …

Balancing cell survival and cell death is fundamental to development and homeostasis. Cell
death is regulated by multiple interconnected signaling pathways and molecular …

NETs are composed of nuclear chromatin, associated with nuclear histones and granular
antimicrobial proteins. They are scaffolds, ideal for retaining microbes. The main function of …