Update in global trends and aetiology of hepatocellular carcinoma
P Rawla, T Sunkara, P Muralidharan… - Contemporary Oncology …, 2018 - termedia.pl
Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver responsible
for an increasing number of cancer-related deaths, especially in develo** economies of …
for an increasing number of cancer-related deaths, especially in develo** economies of …
[HTML][HTML] miR-122–a key factor and therapeutic target in liver disease
Being the largest internal organ of the human body with the unique ability of self-
regeneration, the liver is involved in a wide variety of vital functions that require highly …
regeneration, the liver is involved in a wide variety of vital functions that require highly …
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells
Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit
immunity to chronic viral infection. Defining novel markers of exhaustion is important both for …
immunity to chronic viral infection. Defining novel markers of exhaustion is important both for …
Predictive validity in drug discovery: what it is, why it matters and how to improve it
JW Scannell, J Bosley, JA Hickman… - Nature Reviews Drug …, 2022 - nature.com
Successful drug discovery is like finding oases of safety and efficacy in chemical and
biological deserts. Screens in disease models, and other decision tools used in drug …
biological deserts. Screens in disease models, and other decision tools used in drug …
The circadian clock and liver function in health and disease
Each day, all organisms are subjected to changes in light intensity because of the Earth's
rotation around its own axis. To anticipate this geo-physical variability, and to appropriately …
rotation around its own axis. To anticipate this geo-physical variability, and to appropriately …
[PDF][PDF] Hepatitis C virus drug resistance–associated substitutions: State of the art summary
E Lontok, P Harrington, A Howe, T Kieffer… - …, 2015 - Wiley Online Library
Hepatitis C virus (HCV) drug development has resulted in treatment regimens composed of
interferon‐free, all‐oral combinations of direct‐acting antivirals. While the new regimens are …
interferon‐free, all‐oral combinations of direct‐acting antivirals. While the new regimens are …
Towards an HBV cure: state-of-the-art and unresolved questions—report of the ANRS workshop on HBV cure
MB Zeisel, J Lucifora, WS Mason, C Sureau, J Beck… - Gut, 2015 - gut.bmj.com
HBV infection is a major cause of liver cirrhosis and hepatocellular carcinoma. Although
HBV infection can be efficiently prevented by vaccination, and treatments are available, to …
HBV infection can be efficiently prevented by vaccination, and treatments are available, to …
[HTML][HTML] Pathogenesis and prevention of hepatitis C virus-induced hepatocellular carcinoma
Hepatitis C virus (HCV) is one of the major aetiologic agents that causes hepatocellular
carcinoma (HCC) by generating an inflammatory, fibrogenic, and carcinogenic tissue …
carcinoma (HCC) by generating an inflammatory, fibrogenic, and carcinogenic tissue …
Molecular liver cancer prevention in cirrhosis by organ transcriptome analysis and lysophosphatidic acid pathway inhibition
Cirrhosis is a milieu that develops hepatocellular carcinoma (HCC), the second most lethal
cancer worldwide. HCC prediction and prevention in cirrhosis are key unmet medical needs …
cancer worldwide. HCC prediction and prevention in cirrhosis are key unmet medical needs …
Improving drug design: an update on recent applications of efficiency metrics, strategies for replacing problematic elements, and compounds in nontraditional drug …
NA Meanwell - Chemical Research in Toxicology, 2016 - ACS Publications
Drug discovery and development is a complex and lengthy enterprise that suffers from high
rates of candidate attrition at all stages of the process. The physical, biological, and …
rates of candidate attrition at all stages of the process. The physical, biological, and …