At present, the idea of genome modification has revolutionized the modern therapeutic
research era. Genome modification studies have traveled a long way from gene …

The discovery of antibiotic drugs is considered one of the previous century's most important
medical discoveries (Medicine's 10 greatest discoveries. New Haven, CT: Yale University …

Chronic airway colonisation by Pseudomonas aeruginosa, a hallmark of cystic fibrosis (CF)
lung disease, is associated with increased morbidity and mortality and despite aggressive …

As highly effective CFTR modulator therapies (HEMT) emerge, there is an unmet need to
find effective drugs for people with CF (PwCF) with ultra-rare mutations who are too few for …

This review presents current updates of pancreatic enzyme replacement therapy in children
with cystic fibrosis based on literature published in the last decade and some special …

Cystic fibrosis (CF) is a lethal autosomal recessive genetic disease, caused by a mutation in
the cystic fibrosis transmembrane conductance regulator gene (CFTR), which primarily …

Whenever Pseudomonas aeruginosa is cultured from cystic fibrosis (CF) patient airways, the
primary goal is eradication by antibiotic therapy. Success is defined by≥ 6 months of …

The course of cystic fibrosis (CF) as a nutritional illness is diverging since the introduction of
highly effective modulator therapy, leading to more heterogeneous phenotypes of the …

Biofilm infections are tolerant to the host responses and recalcitrance to antibiotic drugs and
disinfectants. The induced host-specific innate and adaptive immune responses by …

Background Pseudomonas aeruginosa is difficult to eradicate from the lungs of cystic
fibrosis (CF) patients due to biofilm formation. Organs and blood are independent …