Thienopyrimidine derivatives hold a unique place between fused pyrimidine compounds.
They are important and widely represented in medicinal chemistry as they are structural …

ABSTRACT “A journey of mixed emotions” is a quote that best describes the progress chart
of vascular endothelial growth factor receptor (VEGFR) inhibitors as cancer therapeutics in …

Abstract New thieno [2, 3‐d] pyrimidine derivatives were designed and synthesized. The
National Cancer Institute (NCI) evaluated the synthesized novel compounds against a panel …

Hepatocellular carcinoma (HCC) ranks as the third most prevalent reason for cancer-related
death on a global scale. Tyrosine kinase inhibitors (TKIs) continue to be the primary …

Abstract Nineteen new quinazolin-4 (3 H)-one derivatives 3a–g and 6a–l were designed
and synthesised to inhibit EGFR. The antiproliferative activity of the synthesised compounds …

ortho-Alkynyl quinone methides are well-known four-atom synthons for direct [4+ n]
cycloaddition in constructing useful oxa-heterocyclic compounds owing to their high …

Herein we reported the design and synthesis of two series comprising twenty-two
benzenesulfonamides that integrate the s-triazine moiety. Target compounds successfully …

Protein kinases (PKs) including RAF, performs a principal role in regulating countless
cellular events such as cell growth, differentiation, and angiogenesis. Overexpression and …

Two series of quinazolinone derivatives were designed and synthesized as dihydrofolate
reductase (DHFR) inhibitors. All compounds were evaluated for their antibacterial and …

Abstract New series of 20 thieno [2, 3‐d] pyrimidine derivatives have been synthesized. The
National Cancer Institute evaluated all the newly synthesized compounds for their …