Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically
associated with abnormal vasculature, which results in a reduced supply of oxygen and …

Naturally fluorescent proteins have revolutionized biology by enabling what was formerly
invisible to be seen clearly. These proteins have allowed us to visualize, in real time …

A series of achiral hypoxia-activated prodrugs were synthesized on the basis of the DNA
cross-linking toxin of the prodrug, ifosfamide. The hypoxia-selective cytotoxicity of several of …

BACKGROUND: Colorectal cancer metastases result in a significant number of cancer
related deaths. The molecular mechanisms underlying this complex, multi-step pathway are …

The multiparametric molecular cell and tissue analysis in vitro and in vivo is characterized by
rapid progress in the field of image generation technologies, sensor biotechnology, and …

We have evaluated the use of the Xenogen IVIS 200 imaging system for real-time
fluorescence protein-based optical imaging of metastatic progression in live animals. We …

Pancreatic cancer is critical for developed countries, where its rate of diagnosis has been
increasing steadily annually. In the past decade, the advances of pancreatic cancer …

Fluorescence‐guided surgery can enhance the surgeon's ability to achieve a complete
oncologic resection. There are a number of tumor‐specific probes being developed with …

We have created a novel fluorescent model of a human ovarian carcinoma xenograft
overexpressing receptor HER2, a promising molecular target of solid tumors. The model is …

Tumor progression and angiogenesis are intimately related. To understand the
interrelationship between these two processes, real-time imaging can make a major …