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Biological role of matrix stiffness in tumor growth and treatment
B Deng, Z Zhao, W Kong, C Han, X Shen… - Journal of translational …, 2022 - Springer
In recent years, the biological role of changes in physical factors in carcinogenesis and
progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is …
progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is …
[HTML][HTML] Extracellular matrix cues regulate mechanosensing and mechanotransduction of cancer cells
CT Mierke - Cells, 2024 - mdpi.com
Extracellular biophysical properties have particular implications for a wide spectrum of
cellular behaviors and functions, including growth, motility, differentiation, apoptosis, gene …
cellular behaviors and functions, including growth, motility, differentiation, apoptosis, gene …
Single‐cell transcriptome atlas of human mesenchymal stem cells exploring cellular heterogeneity
Z Wang, C Chai, R Wang, Y Feng… - Clinical and …, 2021 - Wiley Online Library
Background The heterogeneity of mesenchymal stem cells (MSCs) is poorly understood,
thus limiting clinical application and basic research reproducibility. Advanced single‐cell …
thus limiting clinical application and basic research reproducibility. Advanced single‐cell …
T cell migration, search strategies and mechanisms
MF Krummel, F Bartumeus, A Gérard - Nature Reviews Immunology, 2016 - nature.com
T cell migration is essential for T cell responses; it allows for the detection of cognate antigen
at the surface of antigen-presenting cells and for interactions with other cells involved in the …
at the surface of antigen-presenting cells and for interactions with other cells involved in the …
Visualizing dynamic microvillar search and stabilization during ligand detection by T cells
E Cai, K Marchuk, P Beemiller, C Beppler… - Science, 2017 - science.org
INTRODUCTION For T cells to mount an adaptive immune response and enact cell-
mediated immunity, they must first successfully detect rare cognate antigen. This detection is …
mediated immunity, they must first successfully detect rare cognate antigen. This detection is …
Central memory and effector memory T cell subsets: function, generation, and maintenance
F Sallusto, J Geginat, A Lanzavecchia - Annu. Rev. Immunol., 2004 - annualreviews.org
The memory T cell pool functions as a dynamic repository of antigen-experienced T
lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that …
lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that …
T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
TR Mempel, SE Henrickson, UH Von Andrian - Nature, 2004 - nature.com
Primary T-cell responses in lymph nodes (LNs) require contact-dependent information
exchange between T cells and dendritic cells (DCs). Because lymphocytes continually enter …
exchange between T cells and dendritic cells (DCs). Because lymphocytes continually enter …
Compensation mechanism in tumor cell migration mesenchymal–amoeboid transition after blocking of pericellular proteolysis
K Wolf, I Mazo, H Leung, K Engelke… - Journal of Cell …, 2003 - rupress.org
The online version of this article includes supplemental material. Address correspondence
to P. Friedl, Department of Dermatology, University of Würzburg, Josef-Schneider-Str. 2 …
to P. Friedl, Department of Dermatology, University of Würzburg, Josef-Schneider-Str. 2 …
Immune modulatory properties of collagen in cancer
AMA Rømer, ML Thorseth, DH Madsen - Frontiers in immunology, 2021 - frontiersin.org
During tumor growth the extracellular matrix (ECM) undergoes dramatic remodeling. The
normal ECM is degraded and substituted with a tumor-specific ECM, which is often of higher …
normal ECM is degraded and substituted with a tumor-specific ECM, which is often of higher …
Chemokines in Innate and Adaptive Host Defense: Basic Chemokinese Grammar for Immune Cells
A Rot, UH Von Andrian - Annu. Rev. Immunol., 2004 - annualreviews.org
▪ Abstract Chemokines compose a sophisticated communication system used by all our cell
types, including immune cells. Chemokine messages are decoded by specific receptors that …
types, including immune cells. Chemokine messages are decoded by specific receptors that …