Factor XIII (FXIII) is a transglutaminase enzyme that catalyses the formation of ε-(γglutamyl)
lysyl isopeptide bonds into protein substrates. The plasma form, FXIIIA2B2, has an …

Factor XIII (FXIII) is a multifunctional pro-γ-transglutaminase that, in addition to its well-
known role in hemostasis, has a crucial role in angiogenesis, maintenance of pregnancy …

Inherited deficiency of FXIII A subunit (FXIII-A) is a rare (1: 2,000,000) but very severe
bleeding diathesis. The incidence is much higher in communities where the practice of …

Factor XIII deficiency (FXIIID) is a rare hereditary bleeding disorder arising from
heterogeneous mutations, which can lead to life‐threatening hemorrhage. The diagnosis of …

Factor XIII deficiency (FXIIID) is a rare bleeding disorder with an estimated prevalence of 1 in
2-million population worldwide. In Iran, a Middle Eastern country with a high rate of …

Coagulation factor XIII (FXIII) acts as a fine fulcrum in blood plasma that maintains the
balance between bleeding and thrombosis by covalently crosslinking the pre-formed fibrin …

Introduction Intracranial haemorrhage in children with inherited bleeding disorders is a
potentially life‐threatening complication and presents a significant therapeutic challenge …

With 473 patients, Iran has about one third of the world's patients with severe congenital
factor XIII (FXIII) deficiency. A considerable number of patients with FXIII deficiency (FXIIID) …

The biologic process of bone healing is complicated, involving a variety of cells, cytokines,
and growth factors. As a result of bone damage, the activation of a clotting cascade leads to …

Despite the early discovery of factor XIII (FXIII) in 1944, the diagnosis of FXIII deficiency was
not made until 1960, after all the other coagulation factor deficiencies, most likely due to the …