Risk of dementia in diabetes mellitus: a systematic review

GJ Biessels, S Staekenborg, E Brunner… - The Lancet …, 2006 - thelancet.com
The relation between diabetes and major types of dementia is controversial. This systematic
review examines the incidence of dementia in people with diabetes mellitus. We identified …

Therapeutic potential of ginsenosides as an adjuvant treatment for diabetes

L Bai, J Gao, F Wei, J Zhao, D Wang… - Frontiers in …, 2018 - frontiersin.org
Ginseng, one of the oldest traditional Chinese medicinal herbs, has been used widely in
China and Asia for thousands of years. Ginsenosides extracted from ginseng, which is …

Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus

RA Whitmer, AJ Karter, K Yaffe, CP Quesenberry… - Jama, 2009 - jamanetwork.com
Context Although acute hypoglycemia may be associated with cognitive impairment in
children with type 1 diabetes, no studies to date have evaluated whether hypoglycemia is a …

Impairment of the glymphatic system after diabetes

Q Jiang, L Zhang, G Ding… - Journal of Cerebral …, 2017 - journals.sagepub.com
The glymphatic system has recently been shown to clear brain extracellular solutes and
abnormalities in glymphatic clearance system may contribute to both initiation and …

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

SE Arnold, I Lucki, BR Brookshire, GC Carlson… - Neurobiology of …, 2014 - Elsevier
Insulin resistance and other features of the metabolic syndrome are increasingly recognized
for their effects on cognitive health. To ascertain mechanisms by which this occurs, we fed …

Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics

RS Jope, CJ Yuskaitis, E Beurel - Neurochemical research, 2007 - Springer
Deciphering what governs inflammation and its effects on tissues is vital for understanding
many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes …

Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study

T Matsuzaki, K Sasaki, Y Tanizaki, J Hata, K Fujimi… - Neurology, 2010 - AAN Enterprises
Objective: We examined the association between diabetes-related factors and pathology of
Alzheimer disease (AD) to evaluate how diabetes affects the pathogenic process of AD …

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Aβ oligomers

FG De Felice, MNN Vieira, TR Bomfim… - Proceedings of the …, 2009 - National Acad Sciences
Synapse deterioration underlying severe memory loss in early Alzheimer's disease (AD) is
thought to be caused by soluble amyloid beta (Aβ) oligomers. Mechanistically, soluble Aβ …

Obesity-induced brain neuroinflammatory and mitochondrial changes

LO Schmitt, JM Gaspar - Metabolites, 2023 - mdpi.com
Obesity is defined as abnormal and excessive fat accumulation, and it is a risk factor for
develo** metabolic and neurodegenerative diseases and cognitive deficits. Obesity is …

Diabetes mellitus and the risk of Alzheimer's disease: a nationwide population-based study

CC Huang, CM Chung, HB Leu, LY Lin, CC Chiu… - PloS one, 2014 - journals.plos.org
Objectives Possible association between diabetes mellitus (DM) and Alzheimer's disease
(AD) has been controversial. This study used a nationwide population-based dataset to …