HIV infection

LG Bekker, C Beyrer, N Mgodi, SR Lewin… - Nature Reviews …, 2023 - nature.com
The AIDS epidemic has been a global public health issue for more than 40 years and has
resulted in~ 40 million deaths. AIDS is caused by the retrovirus, HIV-1, which is transmitted …

Characteristics, prevention, and management of cardiovascular disease in people living with HIV: a scientific statement from the American Heart Association

MJ Feinstein, PY Hsue, LA Benjamin, GS Bloomfield… - Circulation, 2019 - Am Heart Assoc
As early and effective antiretroviral therapy has become more widespread, HIV has
transitioned from a progressive, fatal disease to a chronic, manageable disease marked by …

Enhanced T cell recovery in HIV-1–infected adults through IL-7 treatment

Y Levy, C Lacabaratz, L Weiss, JP Viard… - The Journal of …, 2009 - Am Soc Clin Investig
HIV infection results in CD4+ T cell deficiency, but efficient combination antiretroviral therapy
(c-ART) restores T cells and decreases morbidity and mortality. However, immune …

Incomplete immune reconstitution in HIV/AIDS patients on antiretroviral therapy: Challenges of immunological non-responders

X Yang, B Su, X Zhang, Y Liu, H Wu… - Journal of leukocyte …, 2020 - academic.oup.com
The morbidity and mortality of HIV type-1 (HIV-1)-related diseases were dramatically
diminished by the grounds of the introduction of potent antiretroviral therapy, which induces …

The end of AIDS: HIV infection as a chronic disease

SG Deeks, SR Lewin, DV Havlir - The lancet, 2013 - thelancet.com
The success of antiretroviral therapy has led some people to now ask whether the end of
AIDS is possible. For patients who are motivated to take therapy and who have access to …

[HTML][HTML] National Lipid Association recommendations for patient-centered management of dyslipidemia: part 2

TA Jacobson, KC Maki, CE Orringer, PH Jones… - Journal of clinical …, 2015 - Elsevier
Abstract An Expert Panel convened by the National Lipid Association previously developed
a consensus set of recommendations for the patient-centered management of dyslipidemia …

Systemic effects of inflammation on health during chronic HIV infection

SG Deeks, R Tracy, DC Douek - Immunity, 2013 - cell.com
Combination antiretroviral therapy for HIV infection improves immune function and
eliminates the risk of AIDS-related complications but does not restore full health. HIV …

Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

CV Fletcher, K Staskus, SW Wietgrefe… - Proceedings of the …, 2014 - National Acad Sciences
Antiretroviral therapy can reduce HIV-1 to undetectable levels in peripheral blood, but the
effectiveness of treatment in suppressing replication in lymphoid tissue reservoirs has not …

Soluble markers of inflammation and coagulation but not T-cell activation predict non–AIDS-defining morbid events during suppressive antiretroviral treatment

AR Tenorio, Y Zheng, RJ Bosch… - The Journal of …, 2014 - academic.oup.com
Background. Defining the association of non–AIDS-defining events with inflammation and
immune activation among human immunodeficiency virus (HIV)–infected persons with …

The activation of bystander CD8+ T cells and their roles in viral infection

TS Kim, EC Shin - Experimental & molecular medicine, 2019 - nature.com
During viral infections, significant numbers of T cells are activated in a T cell receptor-
independent and cytokine-dependent manner, a phenomenon referred to as “bystander …