Evolution and disorder

CJ Brown, AK Johnson, AK Dunker… - Current opinion in …, 2011 - Elsevier
The evolution of disordered proteins or regions of proteins differs from that of ordered
proteins because of the differences in their sequence composition, intramolecular contacts …

From Water and Ions to Crowded Biomacromolecules: In Vivo Structuring of a Prokaryotic Cell

J Spitzer - Microbiology and molecular biology reviews, 2011 - journals.asm.org
The interactions and processes which structure prokaryotic cytoplasm (water, ions,
metabolites, and biomacromolecules) and ensure the fidelity of the cell cycle are reviewed …

Exploration of biarsenical chemistry—challenges in protein research

A Pomorski, A Krężel - ChemBioChem, 2011 - Wiley Online Library
The fluorescent modification of proteins (with genetically encoded low‐molecular‐mass
fluorophores, affinity probes, or other chemically active species) is extraordinarily useful for …

Structural divergence is more extensive than sequence divergence for a family of intrinsically disordered proteins

W Borcherds, S Kashtanov, H Wu… - Proteins: Structure …, 2013 - Wiley Online Library
The p53 transactivation domain (p53TAD) is an intrinsically disordered protein (IDP) domain
that undergoes coupled folding and binding when interacting with partner proteins like the …

The ionic liquid [C 4 mpy][Tf 2 N] induces bound-like structure in the intrinsically disordered protein FlgM

EE Carter, AJ Heyert, M De Souza, JL Baker… - Physical Chemistry …, 2019 - pubs.rsc.org
The A. aeolicus intrinsically disordered protein FlgM has four well-defined α-helices when
bound to σ28, but in water FlgM undergoes a change in tertiary structure. In this work, we …

The role of semidisorder in temperature adaptation of bacterial FlgM proteins

J Wang, Y Yang, Z Cao, Z Li, H Zhao, Y Zhou - Biophysical Journal, 2013 - cell.com
Probabilities of disorder for FlgM proteins of 39 species whose optimal growth temperature
ranges from 273 K (0° C) to 368 K (95° C) were predicted by a newly developed method …

FlgM proteins from different bacteria exhibit different structural characteristics

WK Ma, R Hendrix, C Stewart, EV Campbell… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Intrinsically disordered proteins (IDPs) are a unique class of proteins that do not require a
stable structure for function. The importance of IDPs in many biological processes has been …

Conformational Change Characteristics in the Intrinsically Disordered FlgM Protein from a Hyperthermophile at Two Different Temperatures

YF ZHU, ZX CAO, LL ZHAO… - Acta Physico-Chimica …, 2015 - ingentaconnect.com
The aim of this work was to compare the structural characteristics of the FlgM protein from
the thermophile aquifex aeolicus at room temperature (293 K) and at the physiological …

[PDF][PDF] Cold Adaptation of Intrinsically Disordered Structure Studied in p53 Homologs

EC Tilton - 2016 - digital.library.txstate.edu
Structural descriptions of functional biology, commonly known as the protein structure-
function paradigm, state that protein function is dependent upon its well defined three …

Influence of environment and temperature on the structure of the thermophilic intrinsically disordered protein FlgM

EE Carter - 2016 - search.proquest.com
Recently, there has been significant interest in intrinsically disordered proteins (IDPs)
because they challenge the postulate that the structure of a protein dictates its function …