AMPK at the nexus of energetics and aging
When energy supply is low, organisms respond by slowing aging and increasing resistance
to diverse age-related pathologies. Targeting the mechanisms underpinning this response …
to diverse age-related pathologies. Targeting the mechanisms underpinning this response …
AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity
Skeletal muscle plays an important role in regulating whole-body energy expenditure given
it is a major site for glucose and lipid oxidation. Obesity and type 2 diabetes are causally …
it is a major site for glucose and lipid oxidation. Obesity and type 2 diabetes are causally …
[HTML][HTML] The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation
Summary Amyloid-β 1–42 (Aβ42) oligomers are synaptotoxic for excitatory cortical and
hippocampal neurons and might play a role in early stages of Alzheimer's disease (AD) …
hippocampal neurons and might play a role in early stages of Alzheimer's disease (AD) …
AMP-activated protein kinase: new regulation, new roles?
D Carling, C Thornton, A Woods… - Biochemical …, 2012 - portlandpress.com
The hydrolysis of ATP drives virtually all of the energy-requiring processes in living cells. A
prerequisite of living cells is that the concentration of ATP needs to be maintained at …
prerequisite of living cells is that the concentration of ATP needs to be maintained at …
Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease
Huntington's disease (HD) is a neurodegenerative disorder that manifests with movement
dysfunction. The expression of mutant Huntingtin (mHTT) disrupts the functions of brain …
dysfunction. The expression of mutant Huntingtin (mHTT) disrupts the functions of brain …
AMPK in the brain: its roles in glucose and neural metabolism
The adenosine monophosphate‐activated protein kinase (AMPK) is an integrative metabolic
sensor that maintains energy balance at the cellular level and plays an important role in …
sensor that maintains energy balance at the cellular level and plays an important role in …
Mitochondrial dysfunction in Huntington's disease
Mitochondrial dysfunction has been described as an early pathological mechanism
delineating the selective neurodegeneration that occurs in Huntington's disease (HD), a …
delineating the selective neurodegeneration that occurs in Huntington's disease (HD), a …
A selective inhibitor of the NLRP3 inflammasome as a potential therapeutic approach for neuroprotection in a transgenic mouse model of Huntington's disease
KP Chen, KF Hua, FT Tsai, TY Lin, CY Cheng… - Journal of …, 2022 - Springer
Background Huntington's disease (HD) is a neurodegenerative disorder caused by the
expansion of the CAG repeat in the huntingtin (HTT) gene. When the number of CAG …
expansion of the CAG repeat in the huntingtin (HTT) gene. When the number of CAG …